Results 81 to 90 of about 471,442 (349)

Stimulation programs for pediatric drug research – do children really benefit? [PDF]

, 2007
Most drugs that are currently prescribed in pediatrics have not been tested in children. Pediatric drug studies are stimulated in the USA by the pediatric exclusivity provision under the Food and Drug Administration Modernization Act (FDAMA) that grants ...
A Ceci, Adam F. Cohen, BV Niclasen, C Pandolfini, C Pandolfini, E Sanz, E Schirm, E Schirm, GL Kearns, GW ‘t Jong, Isabelle Boots, J Ramet, Jacobus Burggraaf, Jan M. Wit, K Rokstad, M Ufer, MA Lewis, N Thrane, PH Caldwell, R Roberts, RE Kauffman, Richard H. Klein, RL Smyth, Robert A. Holl, Rám N. Sukhai, S Conroy   +25 more
core   +2 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

ADME Gene-Related Pharmacogenomic Labeling of FDA-Approved Drugs: Comparison with Clinical Pharmacogenetics Implementation Consortium (CPIC) Evidence Levels

Medicines
Pharmacogenomics (PGx) can facilitate the transition to patient-specific drug regimens and thus improve their efficacy and reduce toxicity. The aim of this study was to evaluate the overlap of PGx classification for drug absorption, distribution ...
Subrata Deb, Robert Hopefl, Anthony Allen Reeves, Dena Cvetkovic   +3 more
doaj   +1 more source

Assessment of primary labeling of medicines manufactured by Nepalese pharmaceutical industries

Journal of Pharmaceutical Policy and Practice, 2018
Background Appropriate labeling of marketed medicines is necessary to fulfill the regulatory provisions and ensure patient medication safety.
Ramesh Sharma Poudel, Shakti Shrestha, Santosh Thapa, Bhupendra Kumar Poudel, Muniraj Chhetri   +4 more
doaj   +1 more source

Radiolabeling of Nanoparticles and Polymers for PET Imaging

Pharmaceuticals, 2014
Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances.
Katharina Stockhofe, Johannes M. Postema, Hanno Schieferstein, Tobias L. Ross   +3 more
doaj   +1 more source

A Deep Learning Approach to the Prediction of Drug Side-Effects on Molecular Graphs [PDF]

arXiv, 2022
Predicting drug side-effects before they occur is a key task in keeping the number of drug-related hospitalizations low and to improve drug discovery processes. Automatic predictors of side-effects generally are not able to process the structure of the drug, resulting in a loss of information.
arxiv  

Pharmacy & Therapeutics Update: Drug Information for Health Care Professionals [PDF]

, 2007
pharmacy, pharmacology, therapeutics, medicine, drug utilization, public health, sodium phosphate, catheter obstruction, weight loss drugs, cathartics, phosphates, colon, anti-obesity agents, drug labeling, United States Food and Drug ...
Bush, Paul, Cooper, Jason, Garrison, Kelli, Lewis, Ashley, Medical University of South Carolina, Wisniewski, Chris   +5 more
core   +18 more sources

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

First Amendment Scrutiny of FDA'S Fight Against Misbranding: Placing Labeling on the Spectrum of Speech [PDF]

, 2012
In order to further the Food and Drug Administration's (FDA) mission of "assur[ing] that the products it regulates are safe and truthfully labeled," the Federal Food, Drug, and Cosmetic Act (FD&C Act) gives FDA the power to enforce prohibitions on ...
Weissman, Kenneth I.
core  

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source