Results 101 to 110 of about 29,921 (309)

Novel nanocrystal-based solid dispersion with high drug loading, enhanced dissolution, and bioavailability of andrographolide

, 2018
Yueqin Ma,1,2,* Yang Yang,2,* Jin Xie,1 Junnan Xu,1 Pengfei Yue,1 Ming Yang1 1Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, 2Department of Medicine and ...
Yang Y, Yue P, Xie J, Yang M, Ma Y, Xu J
core  

Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics [PDF]

, 2008
Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the mRNA sequence of the target gene.
Alirio J. Melendez, Mansoor, Moizza, Moizza Mansoor, Melendez, Alirio J.   +3 more
core   +1 more source

Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment

International Journal of Nanomedicine
Yilin Chen,1,2 Zi Ye,1,2 Haixu Chen,3 Zhaohui Li1,2 1School of Medicine, Nankai University, Tianjin, People’s Republic of China; 2Senior Department of Ophthalmology, The Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of ...
Chen Y, Ye Z, Chen H, Li Z
doaj  

Delivery of baicalein and paclitaxel using self-assembled nanoparticles: synergistic antitumor effect in vitro and in vivo

International Journal of Nanomedicine, 2015
Wei Wang,1,* Mei Xi,2,* Xuezhong Duan,1 Yong Wang,3 Fansheng Kong4 1Department of Chinese Medicine Integrated Traditional Chinese Medicine and Western Medicine, General Hospital of Ji’nan Command, People’s Liberation Army, 2Emergency ...
Wang W, Xi M, Duan X, Wang Y, Kong F
doaj  

Transfusion burden and willingness to pay for temporary alleviation of anemia status in transfusion-dependent beta-thalassemia patients in China

BMC Health Services Research
Background Transfusion-dependent β-thalassemia (TDT) is one of the global public health concerns highlighted by the World Health Organization. Patients with TDT require regular blood transfusion to survive. However, the availability of blood resources is
Shirui Chen, Yueyue Liu, Xiaolin Yin, Quanyi Lu, Xiangzhou Du, Rong Huang, Yu Jia, Xin Wang, Xiaoyu Xi   +8 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

NANOSPONGES: NOVEL STRATEGY FOR TARGETED DRUG DELIVERY SYSTEM: A REVIEW

, 2020
Owing to miniaturisation, dose-depletion, continuous and restrictive liberation of active substances, well established material constancy, the field concerned with advanced nanostructured systems has seen rapid growth in recent years.
Kaur Navdeep*, Kumar Sandeep
core   +1 more source

[The formulation aspects of drug liberation].

Acta pharmaceutica Hungarica, 1993
Author raised problems and showed through research data some simple possibilities to achieve controlled release drug liberation. The dosage form developed during drug formulation work may influence the biological effects exerted by the active ingredients and therefore may alter the therapeutic efficacy, too.
openaire   +1 more source