Results 121 to 130 of about 29,921 (309)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Logic and Limits of Animal Liberation
, 1984 The current interest in treatment towards animals goes beyond the focus of isolated instances of brutality and encompasses the advocacy of significant changes in our traditional attitudes toward animals. In one year (1980) an estimated 2,054,281,000 hogs,
Bennett, Edward R.
core
Physicochemical Properties and Release Profiles of Lidocaine Hydrochloride in Microemulsion Gels
European Pharmaceutical JournalThis study focuses on the development and characterization of microemulsion gel systems incorporating the model drug lidocaine. Microemulsions were prepared via the standard phase titration method using various oil phases, surfactants, and co-surfactants,
Jackuliaková Patrícia +4 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Frontiers in Bioengineering and BiotechnologySpinal cord injury (SCI) is a pathological condition that damages the central nervous system. Due to the persistence of neuroinflammation after injury, the prognosis is often poor.
Wenshui Li +17 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
A MULTIPURPOSE AND NOVEL CARRIER FOR DRUG DELIVERY AND TARGETING - VIROSOMES
, 2013 There is presently passionate investigation bustle aimed at the improvement of new delivery systems for vaccines. The aspiration is to identify best possible methods for presenting target antigens to the immune system in a manner that will elicit immune ...
Patel, M, Lad, C, Vyas, R B, Kapoor, D
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Qualitative findings from North America's first drug compassion club.
In Canada, the ongoing fatal overdose crisis remains driven by the unpredictable potency and content of the illicit drug supply. From August 2022 until October 2023, the Drug User Liberation Front [DULF] operated a drug compassion club [CC], which sells ...
Jeremy Kalicum +3 more
core +1 more source