Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Entwicklung und Charakterisierung von Nanosuspensionen auf Basis erstarrter invers mizellarer Lösungen (SRMS) als ophthalmologisches Drug Delivery System [PDF]
, 2004 Nanosuspensionen auf Basis erstarrter invers mizellarer Lösungen (SRMS, Lecithin (Le)/Hartfett-Mischungen) als ophthalmologisches Drug Delivery System haben zum Ziel, schwer lösliche Arzneistoffe (AS) als wässriges, gut anwendbares System zu formulieren ...
Friedrich, Ingo
core +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Neighboring Group-Controlled Hydrolysis: Towards “Designer” Drug Release Biomaterials
, 2007 To give the first demonstration of neighboring group-controlled drug delivery rates, a series of novel, polymerizable ester drug conjugates was synthesized and fully characterized.
Morrow, R.J. +4 more
core +1 more source
An Overview of In Vitro Drug Release Methods for Drug-Eluting Stents
, 2022 The drug release profile of drug-eluting stents (DESs) is affected by a number of factors, including the formulation, design, and physicochemical properties of the utilized material.
Nader Zirak +9 more
core +1 more source
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2019 Introdution: Common cancer treatment methods have many side effects. Therefore, the use of new methods for drug delivery to cancer cells is necessary. In the present study, nano formulations of lipid carriers containing doxorubicin have been synthesized ...
Syed-Mohammad Moosavizadeh +4 more
doaj
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Rational design of a dual-mode optical and chemical prodrug
, 2007 Purpose. The purpose of this study is to demonstrate the rational design and behaviour of the first dual mode optical and chemical prodrug, exemplified by an acetyl salicylic acid-based system. Methods. A cyclic 1,4-benzodioxinone prodrug was synthesised
Nieuwenhuyzen, Mark +4 more
core +1 more source
Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker [PDF]
, 2018 PEGylation typically improves the systemic exposure and tumor biodistribution of polymeric drug delivery systems, but may also restrict enzyme access to peptide-based drug linkers. The impact of dendrimer generation (G4 vs G5) and PEG length (570 vs 1100
Christopher J.H. Porter +23 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source