Results 61 to 70 of about 29,921 (309)

When need is greatest, help may be closest: Significance of the spiritual dimension in therapy mediated by interviewees

Cogent Psychology, 2019
In critical situations, the need for change is urgent. The focus in this article is on such situations, because then the inclusion of the spiritual dimension may be particularly significant.
Berit Borgen
doaj   +1 more source

UHPLC-QTOFMS-Based Metabolomic Analysis of the Hippocampus in Hypoxia Preconditioned Mouse

Frontiers in Physiology, 2019
Background: Hypoxia appears in a number of extreme environments, including high altitudes, the deep sea, and during aviation, and occurs in cancer, cardiovascular disease, respiratory failures and neurological disorders. Though it is well recognized that
Wen-Ting Liao, Jie Liu, Jie Liu, Si-Min Zhou, Si-Min Zhou, Gang Xu, Gang Xu, Yu-Qi Gao, Yu-Qi Gao, Wen-Yuan Liu   +9 more
doaj   +1 more source

HISTAMINE LIBERATION INTO THE CEREBROSPINAL FLUID BY THE DRUGS APPLIED INTRAVENTRICULAR!.Y

Japanese Journal of Pharmacology, 1969
Morphine, tubocurarine and veratrine are known to cause motor excitement, hypertension and tachypnea, when they are applied into the cerebrospinal fluid (1-3). Since these drugs have completely different chemical structures, it appears rather strange to elicit analogous excitatory actions on the central nervous system.
TANAKA, KIYOSHI, LIN, YUCHOU
openaire   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

In vitro evaluation of PLA nanoparticles containing a lipophilic drug in water-soluble or insoluble form

, 2004
Cloricromene (AD6), an anti-ischemic drug, is rapidly metabolised into a stable and active metabolite (cloricromene acid, AD6-acid) poorly soluble in water and less lipophilic than cloricromene.
FORNI, Flavio, BRINA, Barbara, VANDELLI, Maria Angela, LEO, Eliana Grazia   +3 more
core   +1 more source

A mechanically interlocked molecular system programmed for the delivery of an anticancer drug [PDF]

, 2015
The development of mechanically interlocked molecular systems programmed to operate autonomously in biological environments is an emerging field of research with potential medicinal applications.
Renoux, Brigitte, Clarhaut, Jonathan, Fernandes, Antony E., Papot, Sébastien, Tranoy-Opalinski, I., Barat, Romain, Legigan, Thibaut, Fernandes, Anthony E., Leigh, David A., Tranoy-Opalinski, Isabelle, Poinot, Pauline, Péraudeau, Elodie, Leigh, David, Aucagne, Vincent   +13 more
core   +1 more source

Protective Effect of Silymarin against Rapamycin-induced Apoptosis and Proliferation Inhibition in Endothelial Progenitor Cells

Natural Product Communications, 2015
For this study, peripheral blood samples were collected from human volunteers. Mononuclear cells (MNC) were separated by density centrifugation and were induced to differentiate into endothelial progenitor cells (EPCs) in vitro . Different concentrations
Peng Zhang, Guohua Han, Pei Gao, Kun Qiao, Yusheng Ren, Chun Liang, Bing Leng, Zonggui Wu   +7 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The child in American evangelicalism and the problem of affluence: A theological anthropology of the Affluent American-Evangelical Child (AAEC) in late modernity [PDF]

, 2005
This thesis presents an evangelical theology of the child in the context of American evangelicalism and affluence. Employing an eclectic theological- critical method, a theological anthropology of the AAEC is developed through an interdisciplinary ...
Sims, David Α.
core  

In vitro biopharmaceutical equivalence of drugs used in the treatment of tuberculosis in Peru [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Medicines are vital for public health, and it is essential to ensure their quality. This is especially important with multisource medications, which have not undergone clinical trials and may have limited bioavailability.
Luis A. Rodríguez-Hidalgo, Pedro M. Alva-Plasencia, Luis A. Concepción-Urteaga, Julio Hilario-Vargas, Olga E. Caballero-Aquiño, Vanessa Saldaña-Bobadilla, Amalia G. Vega-Fernandez   +6 more
doaj   +1 more source