Results 41 to 50 of about 29,921 (309)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Mechanisms of increased bioavailability through amorphous solid dispersions: a review
Drug Delivery, 2020 Amorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble drugs. However, their use in drug development is comparably rare due to a lack of basic understanding of mechanisms governing drug liberation and absorption in ...
Andreas Schittny +2 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Infection and Drug Resistance, 2023 Jin-Hu Shi,1,* Jian Ding,2,* Hu Cheng,1,* Huang Fang,3 Jian Zhu4 1Department of Cardiology, General Hospital of Central Theater Command of the People’s Liberation Army, Wuhan, People’s Republic of China; 2Department of Disinfection and Supply,
Shi JH, Ding J, Cheng H, Fang H, Zhu J
doaj
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Fluoride-Releasing Restorative Materials: the Effect of a Resinous Coat on Ion Release
Acta Stomatologica Croatica, 2020 Objective: To determine the effect of two adhesive systems and a glass ionomer coating resin on fluoride release and concurrent pH changes over a period of 168 days.
Katarina Kelić +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Biosensor measurement of purine release from cerebellar cultures and slices [PDF]
, 2010 We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Eason, Robert +5 more
core +1 more source
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2018 Introdution: Chemotherapy is one of most effective methods to fight metastatic tumors. Its non- targeting has many side effects. The aim of this study was to investigate various formulations of Lipo-Niosomal hybrid system to achieve an optimized and ...
Elham Sasani +4 more
doaj
Frontiers in Bioscience-LandmarkBackground: With the recent evolution of multidrug-resistant strains, the genetic characteristics of foodborne Salmonella enterica serovar Enteritidis and clinical isolates have changed. ST11 is now the most common genotype associated with S. Enteritidis
Jie Liu +8 more
doaj +1 more source