Results 11 to 20 of about 6,868,569 (338)
Current trends in drug metabolism and pharmacokinetics [PDF]
Acta Pharmaceutica Sinica B, 2019 Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion (ADME) processes of a drug. Understanding PK properties is essential for drug development and precision medication.
Yu-hua Li +12 more
semanticscholar +3 more sources
Drug metabolism by flavin-containing monooxygenases of human and mouse [PDF]
Expert Opinion on Drug Metabolism & Toxicology, 2017 Introduction: Flavin-containing monooxygenases (FMOs) play an important role in drug metabolism. / Areas covered: We focus on the role of FMOs in the metabolism of drugs in human and mouse.
I. Phillips, E. Shephard
semanticscholar +3 more sources
Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]
, 2020 Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher +8 more
core +1 more source
Acta Pharmaceutica Sinica B, 2022 d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS, also known as vitamin E-TPGS) is a biodegradable amphiphilic polymer prepared by esterification of vitamin E with polyethylene glycol (PEG) 1000.
Tianming Ren +5 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Biowaiver based on the biopharmaceutics classification system (BCS) has been widely used in the global market for the approval of new generic drug products to avoid unnecessary in vivo bioequivalence (BE) studies.
Xian Zhang +7 more
doaj +1 more source
Scientific Reports, 2020 Oligonucleotide therapeutics use short interfering RNA (siRNA) or antisense oligonucleotide (ASO) molecules to exploit endogenous systems—neutralizing target RNA to prevent subsequent protein translation. While the potential clinical application is vast,
Mai B. Thayer +5 more
doaj +1 more source
mAbs, 2020 The decision to pursue a monoclonal antibody (mAb) as a therapeutic for disease intervention requires the assessment of many factors, such as target-biology, including the total target burden and its accessibility at the intended site of action, as well ...
Kip P. Conner +5 more
doaj +1 more source
Doxycycline alters metabolism and proliferation of human cell lines. [PDF]
, 2013 The tetracycline antibiotics are widely used in biomedical research as mediators of inducible gene expression systems. Despite many known effects of tetracyclines on mammalian cells-including inhibition of the mitochondrial ribosome-there have been few ...
Ahler, Ethan +7 more
core +6 more sources
Pharmacology and Therapeutics, 2013 Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging to the CYP1, 2, and 3 families, are responsible for the biotransformation of most
U. Zanger, M. Schwab
semanticscholar +1 more source
Pharmacology Research & Perspectives, 2020 The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [14C]praliciguat were evaluated following oral administration of a 3‐mg/kg dose in Sprague‐Dawley rats and in a quantitative whole‐body autoradiography (QWBA ...
Ali R. Banijamali +10 more
doaj +1 more source