Results 231 to 240 of about 6,868,569 (338)

Ex vivo Drug Metabolism Using Primary Human Hepatocytes for the Detection of Metabolite-Dependent Antibodies to Red Blood Cells. [PDF]

Transfus Med Hemother
Mayer B, Kurth F, Damm G, Seehofer D, Salama A.   +4 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Autophagy and PXR Crosstalk in the Regulation of Cancer Drug Metabolism and Resistance According to Gene Mutational Status in Colorectal Cancer. [PDF]

Genes (Basel)
Koustas E, Sarantis P, Trifylli EM, Dikoglou-Tzanetatou E, Ioakeimidou E, Anastasiou IA, Karamouzis MV, Theocharis S.   +7 more
europepmc   +1 more source

Pharmacokinetics of FK 506 in transplant patients [PDF]

, 1991
Abu-Elmagd, K, Alessiani, M, Flowers, J, Fung, J, Jain, A, Krajak, A, Lever, J, Mehta, S, Starzl, TE, Todo, S, Venkataramanan, R, Warty, VS, Zuckerman, S   +12 more
core  

Numerical Investigation of a Dual‐Mode Shape Memory Alloy Stent Enabling Secondary Expansion via Focused Ultrasound: A Potential Strategy for Correcting In‐Stent Restenosis

Advanced Engineering Materials, EarlyView.
This study demonstrates a novel noninvasive strategy to treat in‐stent restenosis using focused ultrasound. A shape memory alloy stent initially expands at body temperature. If restenosis occurs, targeted ultrasound heating thermally actuates the stent, enabling a secondary expansion to reopen the blocked vessel, offering a potential alternative to ...
Stephen Asare, Lucinda Duncan, Josiah Owusu‐Danquah, Brian L. Davis   +3 more
wiley   +1 more source

Erratum to "Inhibitory effects of Δ8-tetrahydrocannabinol on major hepatic cytochrome P450 enzymes and implications for drug disposition" [Drug Metabolism and Disposition 53 (2025) 100122]. [PDF]

Drug Metab Dispos
Zhao M, Coates S, Bardhi K, Lazarus P.
europepmc   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

CYP3A-Mediated Carbon-Carbon Bond Cleavages in Drug Metabolism. [PDF]

Biomolecules
Zhou J, Qin X, Zhou S, MacKenzie KR, Li F.   +4 more
europepmc   +1 more source

Haloacid dehalogenase proteins: Novel mediators of metabolic plasticity in Plasmodium falciparum [PDF]

, 2019
Frasse, Philip M., Odom John, Audrey R.
core   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source