Results 211 to 220 of about 852,116 (265)
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Moonlighting in drug metabolism
Drug Metabolism Reviews, 2020Drug metabolizing enzymes catalyze the biotransformation of many of drugs and chemicals. The drug metabolizing enzymes are distributed among several evolutionary families and catalyze a range of detoxication reactions, including oxidation/reduction, conjugative, and hydrolytic reactions that serve to detoxify potentially toxic compounds.
Philip G. Board, M. W. Anders
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The Evolution of Drug Metabolism
Pharmacology, 2000So-called ‘drug-metabolizing enzyme’ (DME) genes have existed on this planet for more than 2.5 billion years and would be more appropriately named ‘effector-metabolizing enzymes’. Genes encoding DMEs have functioned in many fundamental processes in prokaryotes and, more recently, in countless critical life processes in plants and animals.
D W, Nebert, M Z, Dieter
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Drug Metabolism as a Mutation — Drug Metabolism in Mutation
Drug Metabolism Reviews, 1976(1976). Drug Metabolism as a Mutation — Drug Metabolism in Mutation. Drug Metabolism Reviews: Vol. 5, No. 2, pp. i-ii.
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Clinical Pharmacology & Therapeutics, 1973
Biochemical mechanisms related to oxidative and conjugative drug biotransformation are outlined, and the present knowledge about the development of the capacity of the human fetal liver to catalyze these reactions is summarized. The possible importance of extrahepatic drug metabolism in the human fetus is also discussed.
A, Rane, F, Sjöqvist, S, Orrenius
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Biochemical mechanisms related to oxidative and conjugative drug biotransformation are outlined, and the present knowledge about the development of the capacity of the human fetal liver to catalyze these reactions is summarized. The possible importance of extrahepatic drug metabolism in the human fetus is also discussed.
A, Rane, F, Sjöqvist, S, Orrenius
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Current Opinion in Allergy and Clinical Immunology, 2001
The skin performs a wide range of active metabolic functions including xenobiotic metabolism involving metabolizing enzymes specific to the skin. In this review we focus on the role of drug metabolism: (i) in allergic reactions to substances of low molecular weight; (ii) in cutaneous vitamin A and D3 metabolism and its modulation; (iii) in the ...
J M, Baron, H F, Merk
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The skin performs a wide range of active metabolic functions including xenobiotic metabolism involving metabolizing enzymes specific to the skin. In this review we focus on the role of drug metabolism: (i) in allergic reactions to substances of low molecular weight; (ii) in cutaneous vitamin A and D3 metabolism and its modulation; (iii) in the ...
J M, Baron, H F, Merk
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Metabolism of psychoactive drugs
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1982Abstract 1. Acetaldehyde, the toxic metabolite of ethanol, appears to accumulate readily in subjects who are lacking the high-affinity isozyme of aldehyde dehydrogenase. The tendency for cumulation may be supported by the inherited presence of the high-activity variant of alcohol dehydrogenase. 2.
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Drug metabolism for the paediatrician
Archives of Disease in Childhood, 2014Drug metabolism importantly determines drug concentrations. The efficacy and safety of many drugs prescribed for children are, therefore, dependent on intraindividual and interindividual variation in drug-metabolising enzyme activity. During growth and development, changes in drug-metabolising enzyme activity result in age-related differences in drug ...
de Wildt, Saskia +2 more
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Pharmacology, 2008
Papers published over 100 years since the beginning of the scientific study of drug metabolism in birds were reviewed. Birds were found to be able to accomplish more than 20 general biotransformation reactions in both functionalization and conjugation. Chickens were the primary subject of study but over 30 species of birds were used.
G P, Pan, J R, Fouts
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Papers published over 100 years since the beginning of the scientific study of drug metabolism in birds were reviewed. Birds were found to be able to accomplish more than 20 general biotransformation reactions in both functionalization and conjugation. Chickens were the primary subject of study but over 30 species of birds were used.
G P, Pan, J R, Fouts
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Clinics in Liver Disease, 2017
Metabolism is a biotransformation process, where endogenous and exogenous compounds are converted to more polar products to facilitate their elimination from the body. The process of metabolism is divided into 3 phases. Phase I metabolism involves functionalization reactions. Phase II drug metabolism is a conjugation reaction.
Raman Venkataramanan
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Metabolism is a biotransformation process, where endogenous and exogenous compounds are converted to more polar products to facilitate their elimination from the body. The process of metabolism is divided into 3 phases. Phase I metabolism involves functionalization reactions. Phase II drug metabolism is a conjugation reaction.
Raman Venkataramanan
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Drug Metabolism and Therapeutics
New England Journal of Medicine, 1969THE rapidly expanding number of therapeutic agents in use and the widespread administration of multiple medications to patients demand an increased awareness of both the metabolic effects of drugs ...
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