Results 221 to 230 of about 852,116 (265)

Drug metabolism in alcoholics

Pharmacology & Therapeutics, 1982
The effects of chronic use of alcohol on drug metabolism are dependent on many variables, which determine the final outcome. The degree of liver injury, the inducing effect of long-term alcohol use and also macromorphological changes connected with advanced stages of alcohol-induced liver injury are of importance.
O, Pelkonen, E, Sotaniemi
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Extramicrosomal drug metabolism

European Journal of Drug Metabolism and Pharmacokinetics, 1979
Drug metabolizing enzymes which are not located in the microsomes such as oxidoreductases are reviewed. It has been reported that a cytoplasmic NAD+-dependent dehydrogenase could be involved in the dehydrogenation of secondary or primary alcohols, and that peroxidases, located in all extranuclear cell-fractions, are able to oxidize certain drugs. Among
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METABOLISM OF DRUGS BY LEUKOCYTES

Drug Metabolism and Drug Interactions, 1994
Neutrophils and monocytes can metabolize drugs to reactive metabolites, especially those drugs that have nitrogen or sulfur in a low oxidation state. The major system involved in this oxidation is the combination of NADPH oxidase and myeloperoxidase which generates HOCl. Although this system is unlikely to be quantitatively important, i.e.
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Curiosities in drug metabolism

Xenobiotica, 2014
1. It is inevitable that during some xenobiotic biotransformation studies, a certain metabolite or degradation product arises of which the identity is uncertain, the route of formation is ambiguous, or it is just a plain mystery. 2. The following communication draws attention to three drugs reported in the literature, chlorphentermine, phenothiazine ...
Stephen C, Mitchell, Rosemary H, Waring, Robert L, Smith   +2 more
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Mammalian Drug Metabolism

Journal of Natural Products, 1983
Drugs and other chemicals that do not occur in mammalian systems are metabolized by a wide variety of enzymes. Reactions catalyzed by these enzymes have been classified into two general phases. Phase I reactions include oxidations, reductions, and hydrolyses, whereas Phase II reactions are broadly defined as conjugation reactions and include ...
S D, Nelson, W P, Gordon
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Drug metabolism and ageing

British Menopause Society Journal, 2005
Older people are major consumers of drugs and because of this, as well as co-morbidity and age-related changes in pharmacokinetics and pharmacodynamics, are at risk of associated adverse drug reactions. While age does not alter drug absorption in a clinically significant way, and age-related changes in volume of drug distribution and protein binding ...
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Stereoselectivity in drug metabolism

Expert Opinion on Drug Metabolism & Toxicology, 2007
Many chiral drugs are used as their racemic mixtures in clinical practice. Two enantiomers of a chiral drug generally differ in pharmacodynamic and/or pharmacokinetic properties as a consequence of the stereoselective interaction with optically active biological macromolecules.
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Drug Metabolism

Scottish Medical Journal, 1972
J, McEwen, I H, Stevenson
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Drug Metabolism in the Elderly

The Journal of Clinical Pharmacology, 1988
C M, Loi, R E, Vestal
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Comparative Drug Metabolism

1969
The tradition of testing the poisonous properties of food and drink by administering the material to animals extends back through the history of mankind. In some civilizations the expediency of employing human beings as professional ‘tasters’ was an acceptable practice.
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