Results 201 to 210 of about 852,116 (265)

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account. [PDF]

Clin Pharmacol Ther
Johansson I, Xanthopoulou EM, Zhou Y, Sanchez-Spitman A, van der Lee M, Wollmann BM, Størset E, Swen JJ, Guchelaar HJ, Molden E, Jukic MM, Ingelman-Sundberg M.   +11 more
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Examining the Impact of Diet-and-Exercise-Induced Weight Loss on Drug Metabolism and Gastric Emptying in Patients with Obesity. [PDF]

J Clin Pharmacol
Liu S, Wang L, Miller N, Waltje A, Abdelnabi M, Zhu HJ, Sun D, Rothberg AE, Pai MP.   +8 more
europepmc   +1 more source

Advanced Liver-on-a-Chip Model for Evaluating Drug Metabolism and Hepatotoxicity. [PDF]

Biosensors (Basel)
Frojdenfal S, Zuchowska A.
europepmc   +1 more source

CYP3A4 and CYP3A5: the crucial roles in clinical drug metabolism and the significant implications of genetic polymorphisms. [PDF]

PeerJ
Zhang Y, Wang Z, Wang Y, Jin W, Zhang Z, Jin L, Qian J, Zheng L.   +7 more
europepmc   +1 more source

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Metabolism, Pharmacogenetics, and Metabolic Drug–Drug Interactions of Antipsychotic Drugs

Cellular and Molecular Neurobiology, 1999
1. Antipsychotic drugs are extensively metabolised by cytochrome P450 (CYP) enzymes. 2. Dispositions of a number of antipsychotic drugs have been shown to cosegregate with polymorphism of CYP2D6. 3. Metabolic drug-drug interactions have frequently been observed when antipsychotics are coadministered with other drugs. 4.
J, Fang, J W, Gorrod
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REVERSIBLE METABOLISM OF DRUGS

Drug Metabolism and Drug Interactions, 1994
Many drugs undergo reversible metabolism. The basis of our understanding of this process is the reversible metabolism of prednisone (PD)-prednisolone (PL). The pharmacokinetics of reversible metabolism requires the use of four area under the curve values integrated into four equations for clearance (CL).
M W, Jann, Y W, Lam, E C, Gray, W H, Chang   +3 more
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Drug metabolism and pharmacokinetics

Drug Metabolism Reviews, 2009
In this article, aspects of absorption, distribution, metabolism, and excretion have been described bearing in mind the pathogenesis of allergic diseases and their possible therapeutic opportunities. The importance of the routes of administration of the different therapeutic groups has been emphasized.
Margherita Strolin, Benedetti, Rhys, Whomsley, Italo, Poggesi, Willi, Cawello, François-Xavier, Mathy, Marie-Laure, Delporte, Peggy, Papeleu, Jean-Baptiste, Watelet   +7 more
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Drug metabolism by placenta

Clinical Pharmacology & Therapeutics, 1973
Measurable catalysis of mixed‐function oxidations of foreign organic compounds in human placental tissues appears to occur only with a limited number of substrates including 3,4‐benzpyrene, 3'‐methyl‐4‐monomethylaminoazobenzene, and N‐monomethylaniline. Evidence now indicates that mixed‐function oxidations of the classical “type 1” drug substrates (the
M R, Juchau, M G, Pedersen, A G, Fantel, T H, Shepard   +3 more
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