Results 21 to 30 of about 9,044,537 (408)

Determination of Osimertinib, Aumolertinib, and Furmonertinib in Human Plasma for Therapeutic Drug Monitoring by UPLC-MS/MS

Molecules, 2022
The third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), osimertinib, aumolertinib, and furmonertinib represent a new treatment option for patients with EGFR p.Thr790 Met (T790 M)-mutated non-small cell lung cancer ...
Ying Li, Lu Meng, Yinling Ma, Yajing Li, Xiaoqing Xing, Caihui Guo, Zhanjun Dong   +6 more
doaj   +1 more source

Structure Analysis of the Interfering Substance N-methyl-2-phenylpropan-1-amine of Methamphetamine in Wastewater

Fayixue Zazhi, 2022
ObjectiveTo analyze the chemical structure of the interfering substance that affects the result of methamphetamine analysis in wastewater.MethodsA combination of GC-MS and liquid chromatography-quadrupole time-of-flight mass spectrometry （LC-QTOF-MS） was
ZHANG Ting-ting, HUANG Yu, ZHANG Xue-jun, CHEN Jie, HUA Zhen-dong   +4 more
doaj   +1 more source

Monitoring drug adherence [PDF]

Transplantation Reviews, 2015
Medication nonadherence is prevalent in transplant recipients and is a major reason for graft loss. The present review discusses the measurement of adherence in transplant recipients and strategies to improve adherence. SOURCES REVIEWED: Since adherence research is not confined to transplant recipients, our literature review included studies relevant ...
Sarah R, Lieber, Jacqueline, Helcer, Eyal, Shemesh   +2 more
openaire   +2 more sources

Therapeutic drug monitoring [PDF]

Current Opinion in Anaesthesiology, 2002
Traditionally, therapeutic drug monitoring has been used for the management of epilepsy, cardiac arrhythmias, asthma and depression. This review provides an update, particularly for the newer clinical applications, and how therapeutic drug monitoring (including use of analytical and interpretation tools) can improve clinical outcomes.Improved drug ...
Gillian M, Shenfield, Raymond G, Morris
openaire   +4 more sources

Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2021
Importance Proactive therapeutic drug monitoring (TDM), defined as individualized drug dosing based on scheduled monitoring of serum drug levels, has been proposed as an alternative to standard therapy to maximize efficacy and safety of infliximab and ...
S. W. Syversen, G. Goll, K. Jørgensen, Ø. Sandanger, J. Sexton, Inge Christoffer Olsen, J. Gehin, D. Warren, M. K. Brun, R. Klaasen, L. Karlsen, G. Noraberg, C. Zettel, M. Ljoså, A. Haugen, Rune Johan Njålla, T. J. Bruun, K. A. Seeberg, B. Michelsen, E. K. Strand, S. Skorpe, I. Blomgren, Y. Bragnes, C. Dotterud, T. Thune, C. Ystrøm, R. Torp, P. Mielnik, C. Mork, T. Kvien, J. Jahnsen, N. Bolstad, E. Haavardsholm   +32 more
semanticscholar   +1 more source

Expert consensus statement on therapeutic drug monitoring and individualization of linezolid

Frontiers in Public Health, 2022
Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring and individualized treatment have been challenged since its approval.
B. Lin, Yangmin Hu, P. Xu, Tao Xu, Chunyan Chen, Lei He, Mi Zhou, Z. Chen, Chunhong Zhang, Xuben Yu, L. Fang, Junfeng Zhu, Y. Ji, Qun Lin, He-qiong Cao, You-Jun Dai, Xiaoyan Lu, Changcheng Shi, Li Li, Changjiang Wang, Xumei Li, Qi Fang, Jing Miao, Zhengyi Zhu, Guangyong Lin, Haichao Zhan, Shiwen Lv, Yalan Zhu, Xin-jun Cai, Yinqing Ying, Meng Chen, Qiong Xu, Yiwen Zhang, Yubin Xu, Pea Federico, Saiping Jiang, Haibin Dai   +36 more
semanticscholar   +1 more source

Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#

Intensive Care Medicine, 2020
This Position Paper aims to review and discuss the available data on therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill adult patients in the intensive care unit (ICU).
M. Abdul-Aziz, J. Alffenaar, M. Bassetti, H. Bracht, G. Dimopoulos, D. Marriott, M. Neely, J. Paiva, F. Pea, F. Sjovall, J. Timsit, A. Udy, S. Wicha, M. Zeitlinger, J. D. De Waele, J. Roberts   +15 more
semanticscholar   +1 more source

Therapeutic Drug Monitoring and Dosage Adjustments of Immunosuppressive Drugs When Combined With Nirmatrelvir/Ritonavir in Patients With COVID-19

Therapeutic Drug Monitoring, 2022
: Nirmatrelvir/ritonavir (Paxlovid) consists of a peptidomimetic inhibitor (nirmatrelvir) of the SARS-CoV-2 main protease and a pharmacokinetic enhancer (ritonavir). It is approved for the treatment of mild-to-moderate COVID-19.
F. Lemaitre, K. Budde, T. van Gelder, S. Bergan, Roland Lawson, Ofelia Noceti, R. Venkataramanan, L. Elens, D. Moes, D. Hesselink, T. Pawiński, K. Johnson-Davis, B. D. de Winter, S. Pattanaik, M. Brunet, S. Masuda, L. Langman   +16 more
semanticscholar   +1 more source

Determination of five prostaglandin analogs in eyelash enhancing cosmetics by LC-MS/MS

Shanghai yufang yixue, 2022
ObjectiveTo determine bimatoprost， tafluprost ethyl amide， latanoprost， travoprost and tafluprost in eyelash enhancing cosmetics by establishing a LC-MS/MS method.MethodsThe samples were extracted with a 50% acetonitrile water solution. A salt mixture （
XU Yong, PAN Chen, HAN Jing, PENG Xingsheng, ZHENG Rong   +4 more
doaj   +1 more source

Therapeutic Drug Monitoring of Ganciclovir: Where Are We?

Therapeutic Drug Monitoring, 2021
Background: Ganciclovir is the mainstay of therapy for the prophylaxis and treatment of Cytomegalovirus. However, therapy with this antiviral agent is hindered by side effects such as myelosuppression, which often leads to therapy cessation. Underdosing,
A. Märtson, A. E. Edwina, H. Kim, M. Knoester, D. Touw, M. Sturkenboom, J. Alffenaar   +6 more
semanticscholar   +1 more source