Results 41 to 50 of about 873,917 (301)

Age Differences in Psychoactive Substance Abuse in Population of the Republic of Belarus

Central European Journal of Sport Sciences and Medicine, 2016
Background. The recent epidemiological studies conducted in Belarus point to a fall in the average age of registered drug abusers and in the age of drug use onset, an increasing proportion of injecting drugs, and addicted persons.
Vladimir Lelevich, Hanna Vinitskaya, Yuliya Sarana, Eugenij Tischenko   +3 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

National drug-related public expenditure online resource.

, 2021
This is the first set of national profiles that the EMCDDA has produced on drug-related public expenditure. The profiles are based on the sections on public expenditure provided by the 27 EU Member States, Croatia, Turkey and Norway in the national ...

core  

The Role of Genetic Polymorphisms in High-Dose Methotrexate Toxicity and Response in Hematological Malignancies: A Systematic Review and Meta-Analysis

Frontiers in Pharmacology, 2021
Objective: High-dose methotrexate (HDMTX) is a mainstay therapeutic agent for the treatment of diverse hematological malignancies, and it plays a significant role in interindividual variability regarding the pharmacokinetics and toxicity.
Zaiwei Song, Zaiwei Song, Zaiwei Song, Yang Hu, Yang Hu, Yang Hu, Yang Hu, Shuang Liu, Shuang Liu, Shuang Liu, Dan Jiang, Dan Jiang, Dan Jiang, Dan Jiang, Zhanmiao Yi, Zhanmiao Yi, Zhanmiao Yi, Mason M. Benjamin, Rongsheng Zhao, Rongsheng Zhao, Rongsheng Zhao   +20 more
doaj   +1 more source

Therapeutic drug monitoring: antiarrhythmic drugs [PDF]

British Journal of Clinical Pharmacology, 1998
Antiarrhythmic agents are traditionally classified according to Vaughan Williams into four classes of action. Class I antiarrhythmic agents include most of the drugs traditionally thought of as antiarrhythmics, and have as a common action, blockade of the fast‐inward sodium channel on myocardium. These agents have a very significant toxicity, and while
T J, Campbell, K M, Williams
openaire   +4 more sources

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Bioanalysis of racemic reboxetine and its desethylated metabolite in a therapeutic drug monitoring setting using solid phase extraction and HPLC

, 2001
Reboxetine isa new antidepressant drug acting as a potent and selective noradrenaline reuptake inhibitor on the noradrenergic neuronal system. Because of an expected interindividual variability in drug metabolism in the clinical practice the need for ...
Peterson, Curt,, Öhman, Daniel,, Bengtsson, Finn,, Norlander, Björn,   +3 more
core   +1 more source

Prediction model of thrombocytopenia on patients using linezolid: a ranked-based covariate selection with multi-center data

Frontiers in Pharmacology
BackgroundThrombocytopenia is a common adverse reaction of linezolid, often leading to severe complications. It is challenging to externally validate directly apply developed in other countries.
Nhi H. Nguyen, Hieu Le, Hieu Le, An Q. Tang, Hang T. H. Nguyen, Ha N. Tran, Tuyen T. Nguyen, Thuc T. N. Bui, Anh T. L. Dang, Oanh T. Khuat, Hoa D. Vu, Nhung T. H. Trinh, Anh H. Nguyen, Anh H. Nguyen   +13 more
doaj   +1 more source

Simultaneous Determination of 15 Mycotoxins in Grains by Solid Phase Extraction with Impurity Adsorption and UPLC/MSMS

Liang you shipin ke-ji, 2021
To establish a method for the simultaneous determination of 15 mycotoxins in grains by ultra performance liquid chromatography tandem mass spectrometry (UPLC/MSMS).
LIU Xiao-xiao, DING Hui, WU Fu-xiang, MIAO Qian, JI Liang-liang, PENG Tao, ZHANG Jing-jing   +6 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source