Results 21 to 30 of about 873,917 (301)

From therapeutic drug monitoring to total drug monitoring and drug-omics

Clinical Chemistry and Laboratory Medicine (CCLM), 2020
Abstract In view of the role of pharmacotherapy in medicine, on the one hand, and the powerful technical possibilities that are now available on the other hand, therapeutic drug monitoring is a surprisingly neglected area of laboratory medicine.
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Development of a Therapeutic Drug Monitoring Strategy for the Optimization of Vincristine Treatment in Pediatric Oncology Populations in Africa

, 2023
Background:Recent studies have reported ethnic differences in vincristine exposure and outcomes such as toxicity. This resulted in the hypothesis of subtherapeutic dosing in African children.
Kaspers, Gertjan J. L., Dorlo, Thomas P. C.,, Van der Heijden, Lisa T.,, Alwin D.R. Huitema, Nijstad, A. Laura, Uittenboogaard, Aniek, Beijnen, Jos H., Aniek Uittenboogaard, Beijnen, Jos H.,, Huitema, Alwin D. R., Huitema, Alwin D. R.,, van der Heijden, Lisa T., Uittenboogaard, Aniek,, Gertjan J.L. Kaspers, Dorlo, Thomas P. C., Lisa T. Van der Heijden, Kaspers, Gertjan J. L.,, Thomas P.C. Dorlo, Jos H. Beijnen, A. Laura Nijstad, Nijstad, A. Laura,   +20 more
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Liquid Chromatography/Tandem Mass Spectrometry for the Simultaneous Determination of Alverine and its Metabolite, Monohydroxy Alverine, in Human Plasma: Application to a Pharmacokinetic Study

E-Journal of Chemistry, 2011
A rapid and sensitive LC-MS-MS method for the determination of alverine (ALV) and its major metabolite, monohydroxy alverine (MHA), in human plasma using imipramine as an internal standard was developed and validated. The analytes were extracted from 0.5
Rahul C. Gavhane, Ketan K. Nerurkar, Ashok M. Kalamkar, Mitesh R. Patil, Satish G. Pingale, Prafullakumar Kulkarni   +5 more
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Therapeutic Drug Monitoring

YAKUGAKU ZASSHI, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tadaaki, Ito, Yumiko, Uchida, Hiromi, Tamura, Shinobu, Hasebe, Masahiro, Igarashi, Masahiro, Hayashi   +5 more
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A Compilation of Serum Concentrations of 12 Antipsychotic Drugs in a Therapeutic Drug Monitoring Setting [PDF]

, 2019
BACKGROUND: No comprehensive collection of routine therapeutic drug monitoring data for antipsychotic drugs has been published. METHODS: In this compilation, data on 12 antipsychotics are presented.
Anna K. Jönsson, Reis, Margareta,, Jönsson, Anna K., Margareta Reis, Spigset, Olav,, Olav Spigset, Jonsson, Anna K.,, Reis, Margareta, Spigset, Olav   +8 more
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Safety and effectiveness of all-oral and injectable-containing, bedaquiline-based long treatment regimen for pre-XDR tuberculosis in Vietnam

Frontiers in Pharmacology, 2022
Background: The World health organization (WHO) recently recommended standardized all-oral shorter regimens for rifampicin resistant Tuberculosis (RR-TB).
Thi Mai Phuong Nguyen, Binh Hoa Nguyen, Thi Thanh Thuy Hoang, Hoang Anh Nguyen, Dinh Hoa Vu, Mai Hoa Nguyen, Bao Ngoc Nguyen, Tom Decroo, Viet Nhung Nguyen   +8 more
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Monitoring drug treatment

BMJ, 2003
Criteria used for screening tests should apply to monitoring We all want our treatments to work, and none of us wishes treatment to cause harm. Monitoring drug treatment is one way of seeing that a treatment works, while protecting the patient from adverse drug effects. For many patients and many treatments clinical evaluation is sufficient.
Munir, Pirmohamed, Robin E, Ferner
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Drug Interactions and Antiretroviral Drug Monitoring [PDF]

Current HIV/AIDS Reports, 2014
Owing to the improved longevity afforded by combination antiretroviral therapy (cART), HIV-infected individuals are developing several non-AIDS-related comorbid conditions. Consequently, medical management of the HIV-infected population is increasingly complex, with a growing list of potential drug-drug interactions (DDIs). This article reviews some of
Matthew, Foy, C John, Sperati, Gregory M, Lucas, Michelle M, Estrella   +3 more
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An Accurate and Effective Method for Measuring Osimertinib by UPLC-TOF-MS and Its Pharmacokinetic Study in Rats

Molecules, 2018
Osimertinib, a new-generation inhibitor of the epidermal growth factor, has been used for the clinical treatment of advanced T790M mutation-positive tumors.
Song-Tao Dong, Ying Li, Hao-Tian Yang, Yin Wu, Ya-Jing Li, Cong-Yang Ding, Lu Meng, Zhan-Jun Dong, Yuan Zhang   +8 more
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Therapeutic drug monitoring of immunosuppressant drugs [PDF]

British Journal of Clinical Pharmacology, 1999
Individualizing a patient’s drug therapy to obtain the optimum balance between therapeutic efficacy and the occurrence of adverse events is the physician’s goal. However, achieving this goal is not always straight forward, being complicated by within and between patient variability in both pharmacokinetics and pharmacodynamics.
A, Johnston, D W, Holt
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