Results 91 to 100 of about 164,898 (351)

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source

Concentrated burdens: how self-interest and partisanship shape opinion on opioid treatment policy [PDF]

, 2019
When does self-interest influence public opinion on contentious public policies? The bulk of theory in political science suggests that self-interest is only a minor force in public opinion.
De Benedictis-Kessner, Justin, Hankinson, Michael   +1 more
core   +1 more source

Development of Teleoperated Robotic System for Remote Intraocular Microsurgery

Advanced Science, EarlyView.
A teleoperated robotic system, characterized by micrometer‐scale precision and a remote center of motion design, is developed and validated to ensure the safety and flexibility of remote intraocular surgery. This system exhibits superior performance in experimental evaluations and holds significant potential for advancing remote microsurgery ...
Andi Xu, Zhangkai Lian, Wenben Chen, Yanlin Li, Jiali Liu, Hongli Liang, Rihui Song, Zikai Lin, Mingyuan Li, Yining Huang, Ling Jin, Zheming Zhang, Xiaoyue Wei, Bingqian Liu, Wei Ma, Tao Li, Hang Shao, Wei Liu, Kun Gao, Xin Zhang, Pisong Yan, Ruiyang Li, Ruixin Wang, Xiaohang Wu, Duoru Lin, Xiang Chen, Jinghui Wang, Xingwu Zhong, Mohammad Ali Nasseri, Kai Huang, Haotian Lin   +30 more
wiley   +1 more source

Healing a Broken System: Veterans and the War on Drugs [PDF]

, 2012
This report examines the plight of returning veterans who struggle with incarceration and psychological wounds of war such as addiction and post-traumatic stress disorder -- and suggests reforms that could improve the health and preserve the freedom of ...

core  

Estimating The Uncertain Effect of the COVID Pandemic on Drug Overdoses [PDF]

, 2023
Ali Moghtaderi, Mark S. Zocchi, Jesse M. Pines, Arvind Venkat, Bernard S. Black   +4 more
openalex   +1 more source

Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

Advanced Science, EarlyView.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou, Zhenfei Zhong, Peng Hu, Weigang Wang, Ying Song, Na Yang, Fangyan He, Yajie Li, Qi Sa, Yanmei Yang, Qinmiao Sun, Tonghua Yang, Beibei Zhang, Dahua Chen   +13 more
wiley   +1 more source

The influence of the built environment on drug misuse and abuse

Journal of Construction Project Management and Innovation
Drug misuse and overdoses (DMO) continue to rise in the United States and around the world. As the COVID-19 pandemic lockdown brought America to a standstill, the drug overdose epidemic took a sharp turn for the worse.
Adewumi Oladele, Edward Onyango, Kyle Esdaille   +2 more
doaj   +1 more source

CASTNet: Community-Attentive Spatio-Temporal Networks for Opioid Overdose Forecasting

, 2019
Opioid overdose is a growing public health crisis in the United States. This crisis, recognized as "opioid epidemic," has widespread societal consequences including the degradation of health, and the increase in crime rates and family problems.
A Kennedy-Hendricks, A Kolodny, AM Ertugrul, DS Burke, H Jalal, M Pierce, M Warner, NB King, PJ Gruenewald, R Hammersley, RA Rudd, S Hochreiter, S Scardapane, T Bennett, T Seddon   +14 more
core   +1 more source

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

Advanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
wiley   +1 more source

Estimating changes in overdose death rates from increasing methamphetamine supply in Ohio: Evidence from crime lab data

Drug and Alcohol Dependence Reports
Background: We investigate the relationship between the supply of methamphetamine and overdose death risk in Ohio. Ohio and the overall US have experienced a marked increase in overdose deaths from methamphetamine combined with fentanyl over the last ...
Daniel Rosenblum, Jeffrey Ondocsin, Sarah G. Mars, Dennis Cauchon, Daniel Ciccarone   +4 more
doaj   +1 more source