Results 111 to 120 of about 164,898 (351)

Prevalence and correlates of experiencing drug-related discrimination among people who use drugs presenting at emergency department at high risk of opioid overdose

, 2023
Shayla Nolen, Taneisha Wilson, Brendan Jacka, Yu Li, Francesca L. Beaudoin, Brandon D. L. Marshall   +5 more
openalex   +1 more source

A Closed‐Loop‐Capable Neural Interface Platform for Deep Brain Modulation via Integrated Non‐Viral Gene Delivery, NIR Optogenetics, and Electrophysiological Recording

Advanced Science, EarlyView.
A multifunctional, 3D porous neural interface combines non‐viral gene delivery and NIR optogenetics to enable minimally invasive, closed‐loop modulation of deep‐brain circuits. Abstract Closed‐loop neuromodulation requires precise, stable, and cell‐specific control of neural circuits with minimal invasiveness.
Chao‐Yi Chu, Zih‐Huei Chen, Chun‐Wei Liang, Pu‐Wei Wu, Wei‐Qing Guo, Bo‐Wei Chen, Chih‐Chia Huang, Ssu‐Ju Li, Ching‐Wen Chang, Yao‐Wen Liang, Shun‐An Kan, Yu‐Chun Lo, Wei‐Chen Huang, You‐Yin Chen, San‐Yuan Chen   +14 more
wiley   +1 more source

Characteristics of Suicides Caused by Drug Overdose in the State of Maryland

Journal of Forensic Science and Medicine, 2015
Suicidal drug overdose is a major public health issue. In the United States, every year more than 33,000 people commit suicides. Our study focused on the characteristics of suicide victims in the state of Maryland.
Ling Li, Xinbiao Liao, Guozhong Zhang, Daming Sun, Tiantong Yang, Keming Yun, Rebecca Phipps, Xiang Zhang, Mary G Ripple, David Fowler   +9 more
doaj   +1 more source

Adverse Effects of Opioid Dependency on Central and Peripheral Aspects of the Neuromuscular System

, 2019
Prevalence of chronic pain and health care costs have caused an escalation of opioid dependency. The current national crisis involving opioid dependency and drug overdose are growing problems that need to be addressed.
Yang, Cindy
core  

Drug Overdose Mortality by State

, 2022
National Center For Health Statistics
openalex   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, EarlyView.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Notes from the Field: Xylazine, a Veterinary Tranquilizer, Identified as an Emerging Novel Substance in Drug Overdose Deaths — Connecticut, 2019–2020 [PDF]

, 2021
Shobha Thangada, Heather A. Clinton, Sarah Ali, Jacqueline Nunez, James R. Gill, Robert F. Lawlor, Susan B. Logan   +6 more
openalex   +1 more source

Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes

Advanced Science, EarlyView.
In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu, Wenpin Qin, Jialu Gao, Yihan Guo, Xiaoxiao Han, Zhangyu Ma, Xiaokang Zhang, Jie He, Jing Liu, Bo Gao, Changjun Li, Lina Niu, Jianfei Yan, Kai Jiao   +13 more
wiley   +1 more source

Confronting the opioid crisis: Practical pain management and strategies: AOA 2018 critical issues symposium [PDF]

, 2019
The United States is in the midst of an opioid crisis. Clinicians have been part of the problem because of overprescribing of narcotics for perioperative pain management.
Hsu, Joseph R, Jahangir, A Alex, Miller, Anna N, Mir, Hassan R, Obremskey, William T   +4 more
core   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source