Spatial Concentration of Opioid Overdose Deaths in Indianapolis: An Application of the Law of Crime Concentration at Place to a Public Health Epidemic [PDF]
, 2019 The law of crime concentration at place has become a criminological axiom and the foundation for one of the strongest evidence-based policing strategies to date.
Carter, Jeremy G. +2 more
core +1 more source
Loneliness and fearfulness are associated with non-fatal drug overdose among people who inject drugs. [PDF]
PLoS OneBackgroundPeople who inject drugs (PWID) experience high rates of drug overdose death with the risk of mortality increasing after each non-fatal event.
Falade-Nwulia O +7 more
europepmc +2 more sources
Advanced Science, EarlyView.PPARα promotes KLF11 expression and recruits KLF11 and YAP1 to form a transcription complex, where KLF11 acts as a brake in PPARα‐YAP1‐mediated glycolysis. Wogonin reshapes the metabolism of macrophages from glycolysis to fatty acid oxidation via activation of the PPARα‐KLF11‐YAP1 pathway, by which wogonin reduces inflammation and foam cell formation ...
Chuanrui Ma +14 more
wiley +1 more source
Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015.
MMWR. Morbidity and mortality weekly report, 2016 The U.S. opioid epidemic is continuing, and drug overdose deaths nearly tripled during 1999-2014. Among 47,055 drug overdose deaths that occurred in 2014 in the United States, 28,647 (60.9%) involved an opioid (1). Illicit opioids are contributing to the
R. A. Rudd +3 more
semanticscholar +1 more source
Using ICD Codes Alone May Misclassify Overdoses Among Perinatal People. [PDF]
INTRODUCTION: As perinatal drug overdoses continue to rise, reliable approaches are needed to monitor overdose trends during pregnancy and postpartum. This analysis aimed to determine the sensitivity, specificity, positive predictive value, and negative ...
Board, Amy +14 more
core +1 more source
Stigma as a fundamental hindrance to the United States opioid overdose crisis response. [PDF]
, 2019 Alexander Tsai and co-authors discuss the role of stigma in responses to the US opioid ...
Barnett, Michael L +9 more
core +2 more sources
Advanced Science, EarlyView.This study introduces a novel therapeutic approach that employs a conductive hydrogel (HEPP) responsive to near‐infrared light, pH levels, and reactive oxygen species. Its goal is to enhance the healing environment affected by elevated glucose levels, insufficient oxygen, and bacterial infections in diabetes‐related wounds.
Tao Zhang +4 more
wiley +1 more source
Preventing opioid overdoses in Europe:a critical assessment of known risk factors and preventative measures [PDF]
, 2012 This report is the outcome of a project into opioid overdoses. The remit was to focus on finding practical methods of overdose prevention. In order to fulfil this remit, a critical review of existing knowledge on overdose prevention was conducted.
Baldacchino, Alex +3 more
core +1 more source
Interrupted time series analysis to evaluate the performance of drug overdose morbidity indicators shows discontinuities across the ICD-9-CM to ICD-10-CM transition [PDF]
, 2021 Introduction: On 1 October 2015, the USA transitioned from the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) to the International Classification of Diseases, 10th Revision (ICD-10-CM).
Davis, James W. +5 more
core +1 more source
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source