Results 61 to 70 of about 78,243 (311)

Ultrashort‐Pulsed Laser Diffusion Enhancement in Liquids for Cold Extraction of Coffee in an Analytically Validated Low‐Fluence Regime

Advanced Photonics Research, EarlyView.
In this article, pulsed laser diffusion enhancement in liquids as an analytically validated laser extraction in liquids method of coffee suspensions in a defined low fluence window is presented. The results confirm the generation of a unique aroma profile and reduced acidity, which is neither attributed to changes in the specific surface area nor ...
Tina Friedenauer, Simela Kordhishte, Wiebke L. M. Narz, Tobias Bessel, Lucie K. Tintrop, Maryam Vosough, Amir Salemi, Cedric Thom, Sven W. Meckelmann, Maximilian Spellauge, Alexander Sommeryns, Christoph Rehbock, Torsten C. Schmidt, Oliver J. Schmitz, Heinz P. Huber, Stephan Barcikowski   +15 more
wiley   +1 more source

Multi‐Material Additive Manufacturing of Soft Robotic Systems: A Comprehensive Review

Advanced Robotics Research, EarlyView.
This review explores the transformative role of multi‐material additive manufacturing (MMAM) in the development of soft robotic systems. It presents current techniques, materials, and design strategies that enable functionally graded and adaptive structures.
Ritik Raj, Quan‐Chen Song, Jia‐Yang Juang   +2 more
wiley   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF

Advanced Science, EarlyView.
USP45 acts as a melanoma suppressor by stabilizing MRGPRF, which weakens the PI3K/AKT pathway, suppresses tumor growth, and reduces melanoma cell migration and invasion. Abstract Melanoma, a highly malignant skin cancer, has seen a rising incidence and death toll. MRGPRF is a novel melanoma suppressor that inhibits the PI3K/AKT pathway.
Wancong Zhang, Liyun Chen, Jing Zhao, Aiwei Ma, Wenqi Shi, Yiwen Zhang, Zixuan Tang, Jiarui Guo, Zaihua Xu, Jianda Zhou, Shijie Tang   +10 more
wiley   +1 more source

The influence of the built environment on drug misuse and abuse

Journal of Construction Project Management and Innovation
Drug misuse and overdoses (DMO) continue to rise in the United States and around the world. As the COVID-19 pandemic lockdown brought America to a standstill, the drug overdose epidemic took a sharp turn for the worse.
Adewumi Oladele, Edward Onyango, Kyle Esdaille   +2 more
doaj   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Estimating changes in overdose death rates from increasing methamphetamine supply in Ohio: Evidence from crime lab data

Drug and Alcohol Dependence Reports
Background: We investigate the relationship between the supply of methamphetamine and overdose death risk in Ohio. Ohio and the overall US have experienced a marked increase in overdose deaths from methamphetamine combined with fentanyl over the last ...
Daniel Rosenblum, Jeffrey Ondocsin, Sarah G. Mars, Dennis Cauchon, Daniel Ciccarone   +4 more
doaj   +1 more source

Neoeriocitrin Targeting Beclin1 Deubiquitination and Autophagy in Osteogenic Differentiation of Human Dental Pulp Stem Cells

Advanced Science, EarlyView.
Neoeriocitrin enhances osteogenesis in hDPSCs and bone regeneration by targeting Beclin1 to inhibit ubiquitination‐mediated degradation, thereby stabilizing Beclin1 and increasing its protein abundance to activate autophagy. Abstract Human dental pulp stem cells (hDPSCs) are dental‐derived mesenchymal stem cells with robust multipotent differentiation ...
Yu Wu, Haotian Liu, Qunyi Wang, Ting Zhang, Rixin Chen, Qiao Yuan, Xin Tong, Wenrong Yang, Yin Xiao, Fuhua Yan   +9 more
wiley   +1 more source

Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics

Advanced Science, EarlyView.
Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan, Enikő Zakar‐Polyák, Anita Adami, Anna A. Abbas, Yogita Sharma, Raquel Garza, Jenny G. Johansson, Diahann A. M. Atacho, Éva Renner, Miklós Palkovits, Csaba Kerepesi, Johan Jakobsson, Karolina Pircs   +12 more
wiley   +1 more source

Characteristics of Suicides Caused by Drug Overdose in the State of Maryland

Journal of Forensic Science and Medicine, 2015
Suicidal drug overdose is a major public health issue. In the United States, every year more than 33,000 people commit suicides. Our study focused on the characteristics of suicide victims in the state of Maryland.
Ling Li, Xinbiao Liao, Guozhong Zhang, Daming Sun, Tiantong Yang, Keming Yun, Rebecca Phipps, Xiang Zhang, Mary G Ripple, David Fowler   +9 more
doaj   +1 more source