Results 61 to 70 of about 164,580 (300)

Drug overdose: prevention and response. Guidance for helplines. [PDF]

, 2004
This report contains a set of guidelines for helpline staff who are sometimes called on to provide information on drug use and overdose. The focus is on accidental overdose in adults.
Derricott, Jon, McLean, Mark
core  

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Psychosocial and contextual correlates of opioid overdose risk among drug users in St. Petersburg, Russia

Harm Reduction Journal, 2009
Background Opioid overdose in Russia is a problem that has grown more severe as heroin abuse expanded over the past decade, yet few studies have explored it in detail.
Ilyuk Ruslan, Krupitsky Evgeny, Blinnikova Ksenia, Torban Mikhail, Green Traci C, Grau Lauretta E, Kozlov Andrei P, Heimer Robert   +7 more
doaj   +1 more source

Supervised Injection Facilities: Legal and Policy Reforms [PDF]

, 2019
The US Centers for Disease Control and Prevention reported that more than 70 000 deaths from drug overdoses occurred in 2017, including prescription and illicit opioids, representing a 6-fold increase since 1999.
Gostin, Lawrence O., Gulinson, Chelsea L., Hodge, James G.   +2 more
core   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Changes in patterns of use and perceptions of cannabis among students in Canada: A decade of data from the Canadian Student Alcohol and Drugs Survey

Drug and Alcohol Dependence Reports
Introduction: The Canadian Student Alcohol and Drugs Survey is a biennial, repeat cross-sectional survey of grade 7–12 students in the Canadian provinces. This study examined cannabis-related behaviours at five timepoints before and after legalization of
Samantha Goodman, Sebastian A. Srugo, Emilia Krzeminska, Hanan Abramovici   +3 more
doaj   +1 more source

Experience of heroin overdose among drug users attending general practice. [PDF]

, 2000
Heroin overdose is responsible for significant mortality. It has not previously been highlighted as an important prevention or care issue for general practitioners involved in the management of drug misuse.
Cullen, Walter, Bury, Gerard, Langton, Deirdre   +2 more
core  

A Bayesian time-to-event pharmacokinetic model for sequential phase I dose-escalation trials with multiple schedules

, 2020
Phase I dose-escalation trials constitute the first step in investigating the safety of potentially promising drugs in humans. Conventional methods for phase I dose-escalation trials are based on a single treatment schedule only.
Friede, Tim, Günhan, Burak Kürsad, Seroutou, Abdelkader, Weber, Sebastian   +3 more
core   +1 more source

Predicting pharmacy naloxone stocking and dispensing following a statewide standing order, Indiana 2016 [PDF]

, 2018
BACKGROUND: While naloxone, the overdose reversal medication, has been available for decades, factors associated with its availability through pharmacies remain unclear.
Agley, J.D., Davis, A., Gassman, R., Hoss, A., Jayawardene, W., Meyerson, B.E., Ritchie, K., Ryder, P.T., Shannon, D.J.   +8 more
core   +1 more source