Results 161 to 170 of about 26,660 (305)

Peer Review #3 of "Network neighborhood operates as a drug repositioning method for cancer treatment (v0.1)"

, 2023
Burcu Bakır-Güngör
openalex   +1 more source

Preservation Palatopharyngoplasty for Obstructive Sleep Apnea: Predictors and Clinical Outcomes

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate clinical outcomes of Preservation Palatopharyngoplasty (PPPP), in a broader cohort, and identify predictors significantly associated with improved surgical outcomes in patients with moderate to severe obstructive sleep apnea (OSA). Study Design A retrospective cohort study. Settings A tertiary care center.
Mohamed Abdelwahab, Ahmed Alhussien, Mohamed F. Kassir, Hank Butehorn, Claire Munhall, Shaun A. Nguyen   +5 more
wiley   +1 more source

Computational drug repositioning approach to predict multi-target therapeutics for epilepsy. [PDF]

Sci Rep
Kumar P, Kumar V, Chauhan R, Saini V, Kumar A.   +4 more
europepmc   +1 more source

Systems pharmacology and drug repositioning- an integrated approach to metabolic diseases [PDF]

, 2012
Michael Luther
openalex   +1 more source

Deep learning‐based H&E‐derived risk scores in colorectal cancer: associations with tumour morphology, biology, and predicted drug response

The Journal of Pathology, EarlyView.
Abstract Over recent years, several deep learning (DL) models have been presented to predict colorectal cancer (CRC) patient survival directly from haematoxylin and eosin (H&E)‐stained routine whole‐slide images (WSIs). Unlike traditional studies that rely on manually defined histopathological features, weakly supervised DL allows training directly on ...
Nic G Reitsam, Xiaofeng Jiang, Junhao Liang, Bianca Grosser, Veselin Grozdanov, Chiara ML Loeffler, Marco Gustav, Tim Lenz, Hannah S Muti, Zunamys I Carrero, Nicholas P West, Philip Quirke, Sebastian Foersch, Moritz Jesinghaus, Wolfram Müller, Tanwei Yuan, Michael Hoffmeister, Hermann Brenner, Jitendra Jonnagaddala, Nicholas J Hawkins, Robyn L Ward, Heike I Grabsch, Bruno Märkl, Jakob N Kather   +23 more
wiley   +1 more source

Integrating population-level and cell-based signatures for drug repositioning. [PDF]

Bioinformatics
He C, Xu Y, Zhou Y, Fan J, Cheng C, Meng R, Wu L, Pan R, Shah RV, Gamazon ER, Zhou D.   +10 more
europepmc   +1 more source

Engineering Dosimetric Excellence In Total Body Irradiation: Tomotherapy‐Driven Protocols for Precision and Reproducibility

Precision Radiation Oncology, EarlyView.
• Objective: Assess helical Tomotherapy‐based TBI for clinical feasibility, dosimetric reproducibility, and in‐vivo accuracy using dual‐orientation simulation and patient‐specific QA. • Methodology: Implementation of ArcCHECK 3D diode array, ionization chamber verification, and in‐vivo dosimetry with OSLDs at 16 anatomical sites to ensure precise dose ...
Sandeep Singh, Dipesh, Supratik Sen, Abhay Kumar Singh, Mahipal, Manindra Bhushan, Jaskaran Singh Sethi, David K. Simson, Munish Gairola   +8 more
wiley   +1 more source

Redefining Breast Cancer Care by Harnessing Computational Drug Repositioning. [PDF]

Medicina (Kaunas)
Jurj ED, Colibășanu D, Vasii SO, Suciu L, Dehelean CA, Udrescu L.   +5 more
europepmc   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

SIMD: Synergistic integration mutualistic platform based on single-cell and proteotranscriptomics for drug repositioning. [PDF]

NPJ Breast Cancer
Lee SY, Song MY, Lee YR, An JH.
europepmc   +1 more source