Results 201 to 210 of about 26,660 (305)

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Exploring the shared gene signatures between rheumatoid arthritis and type 2 diabetes and their implication for drug repositioning on bioinformatics analysis. [PDF]

Medicine (Baltimore)
Qu X, Zuo X, Du H, Chen Y, Zhang Q, Peng H, Ma K, Zhang F, Cai Y, Tan L, Deng H, Chen X.   +11 more
europepmc   +1 more source

Medical haematology: Repositioning haematology at the centre of medicine

British Journal of Haematology, EarlyView.
The complementary domains of Medical Haematology and Haemato‐Oncology share a biological framework. The left panel depicts red cells, platelets, coagulation, thrombosis and innate immunity, while the right panel shows lymphoid and myeloid malignancies.
Cheng Hock Toh, Imelda Bates, Sue Pavord
wiley   +1 more source

Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

, 2012
Feixiong Cheng, Chuang Liu, Jing Jiang, Weiqiang Lü, Weihua Li, Guixia Liu, Wei‐Xing Zhou, Jin Huang, Yun Tang   +8 more
openalex   +2 more sources

A Systems Biology and Drug Repositioning Approach for the Analysis of Mutual Genes Between Celiac Disease and Irritable Bowel Syndrome. [PDF]

Biomed Res Int
Al-Madhagi H.
europepmc   +1 more source

Repositioning of Drugs as a Promising Strategy to Fight COVID-19

, 2020
Vivek Yadav, Jurnal Reang, Vinita Sharma, Jaseela Majeed, Swaminathan Jambulingam, Ramesh K. Goyal, Rajiv Kumar Tonk   +6 more
openalex   +1 more source

Middle to Late Pleistocene landscape evolution and glacial dynamics in the Eastern Alps: the Gröbminger Mitterberg record, Austria

Boreas, EarlyView.
Glacial erosion during the Last Glacial Maximum (LGM) has removed much evidence of earlier glaciations and interglacials in the European Alps. At Gröbminger Mitterberg (GM), beneath a blanket of LGM till, a distinctive sediment archive preserves deposits predating the LGM.
Gerit E. U. Griesmeier, Daniel P. Le Heron, Christopher Lüthgens, Gustav Firla, Bernhard Salcher, Fabian Dremel, Jan‐Christoph Otto, Jürgen M. Reitner   +7 more
wiley   +1 more source

Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho, Raquel Tonello, Evelyne Silva Brum, Gabriela Becker, Nigel W. Bunnett, Sara Marchesan Oliveira   +5 more
wiley   +1 more source

Genome-wide association study -Driven drug repositioning for the treatment of insomnia. [PDF]

J Genet Eng Biotechnol
Satria RD, Adikusuma W, Sukorini U, Avitasari DE, Kusuma Harahap IS, Setia Lesmana MH, Irham LM, Fatimah Harahap NI, Rinastiti P, Wardhana DA, Prabasaktya RW, Lin CF, Paramitasari A, Kusumadewi AF.   +13 more
europepmc   +1 more source

Repositioning antimalarial drugs as anticancer agents: focus on Tafenoquine

Christopher E. Barton, Bailey Blair, Libby Godo, Andy Gray, Lydia Heron-Goar, Holly A. Hill, Amanda Long, H. S. Moore, Rylee Rickett, Sejersen Tomas   +9 more
openalex   +1 more source