Results 211 to 220 of about 26,660 (305)

TGF‐β Inhibitor Potentiates Osimertinib‐Induced Anti‐Tumor Immunity in Egfr‐Mutant Lung Cancer

Cancer Science, EarlyView.
Osimertinib enhances CD8+ T cell activity but also upregulates immunosuppressive TGF‐β in Egfr‐mutant lung tumors. This study demonstrates that TGF‐β inhibition with nintedanib or vactosertib potentiates osimertinib‐induced CD8+ T cell–mediated immunity and reduce CD206+ macrophages. These findings provide a strong rationale for novel immunotherapeutic
Tadahiro Kuribayashi, Jun Nishimura, Sachi Okawa, Masataka Taoka, Shunta Mori, Takaaki Tanaka, Tomoka Nishimura, Ayako Morita, Naofumi Hara, Kiichiro Ninomiya, Go Makimoto, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Yosuke Togashi, Yoshinobu Maeda, Katsuyuki Kiura, Kadoaki Ohashi   +17 more
wiley   +1 more source

[Drug repositioning prediction based on dynamic feature learning on heterogeneous graphs]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Zhu H, Guo Y, Xin X, Li C, Zhou D.
europepmc   +1 more source

A medicinal chemistry approach to drug repositioning in the treatment of tuberculosis and malaria

, 2016
Gurminder Kaur
openalex   +1 more source

Negotiating Responsibility: Professionals' Perspectives on Separated Parents' Protective Duties in the Swedish Context

Child &Family Social Work, EarlyView.
ABSTRACT This study explores how social workers perceive and enact informal protective arrangements in the context of Swedish child protection. Drawing on group interviews with practitioners, the findings reveal that social workers underline parents' legal obligation and duty to protect their children, which means that the safe parent is expected to ...
Emma Rindeskog, Lupita Svensson
wiley   +1 more source

Drug repositioning model based on knowledge graph embedding. [PDF]

Sci Rep
He S, Zhao X.
europepmc   +1 more source

管我们是因为爱我们 To Guan Us Is to Love Us: Understanding Guan Through Adolescent Perceptions

Children &Society, EarlyView.
ABSTRACT This paper investigates how children interpret the practice of guan (Chinese parenting) within the home and its relationship to family language policy (FLP). The study involved nine adolescent participants from six families. Using a written reflective task, the study explores the attitudes of adolescents towards the practice of guan and its ...
Angie Baily, Xiao Lan Curdt‐Christiansen   +1 more
wiley   +1 more source

MAPTrans: mutual attention transformer with dynamic meta-path pruning for drug repositioning. [PDF]

Brief Bioinform
Ding S, Niu D, Wang X, Zhang Z, Zhang Q, Xiao J, Li Z.   +6 more
europepmc   +1 more source

Evaluating the Impact of Putative Metformin Targets on Cancer Outcomes: A Drug‐Target Mendelian Randomization Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Observational studies show metformin use associated with lower cancer risk, although experimental evidence is inconsistent. To provide genetic validation for repositioning of metformin in cancer prevention, we assessed genetically proxied effects of putative metformin targets on cancer outcomes using a drug‐target Mendelian randomization (
Xingyu Shen, Shan Luo, Jie Zheng, Celine Sze Ling Chui, Ian Chi Kei Wong, Eric Yuk Fai Wan, Catherine Mary Schooling, Shiu Lun Au Yeung   +7 more
wiley   +1 more source

Multi-omics based and AI-driven drug repositioning for epigenetic therapy in female malignancies. [PDF]

J Transl Med
Salvati A, Melone V, Giordano A, Lamberti J, Palumbo D, Palo L, Rea D, Memoli D, Simonis V, Alexandrova E, Silvestro F, Rizzo F, Weisz A, Tarallo R, Nassa G.   +14 more
europepmc   +1 more source

RNA sequencing identifies lung cancer lineage and facilitates drug repositioning

Longjin Zeng, Longyao Zhang, Lingchen Li, Xingyun Liao, Chenrui Yin, Lincheng Zhang, Xiewan Chen, Jianguo Sun   +7 more
openalex   +1 more source