Results 271 to 280 of about 26,660 (305)
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2017
This chapter focuses on the basic elements of computational drug repositioning and overviews the various in silico, in vivo, and in vitro approaches. It describes the use of Systematic Drug Repositioning (SDR) technologies to predict hitherto unknown adverse drug reactions (ADRs), or to derive mechanistic explanations of known ADRs.
Spyros N. Deftereos +5 more
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This chapter focuses on the basic elements of computational drug repositioning and overviews the various in silico, in vivo, and in vitro approaches. It describes the use of Systematic Drug Repositioning (SDR) technologies to predict hitherto unknown adverse drug reactions (ADRs), or to derive mechanistic explanations of known ADRs.
Spyros N. Deftereos +5 more
openaire +1 more source
Repositioning Drugs: A Computational Approach
Current Drug Research ReviewsAbstract: Computational drug repositioning has emerged as an efficient approach to discovering new indications for existing drugs, offering lower risk and cost compared to traditional drug discovery methods.
Bhawna Sharma +5 more
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La Revue du praticien
DRUG REPOSITIONING. Developing new therapeutic agents ("de novo") for human diseases is an increasingly lengthy and costly process, aimed at ensuring patient safety and drug efficacy. An alternative approach, drug repurposing or repositioning, involves using already commercialized or advanced molecules.
Clémence, Réda +2 more
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DRUG REPOSITIONING. Developing new therapeutic agents ("de novo") for human diseases is an increasingly lengthy and costly process, aimed at ensuring patient safety and drug efficacy. An alternative approach, drug repurposing or repositioning, involves using already commercialized or advanced molecules.
Clémence, Réda +2 more
openaire +1 more source
Computational Drug Repositioning for Cancer Therapeutics
Current Topics in Medicinal Chemistry, 2015Due to ever-increasing failure rates, high cost, unsatisfactory safety profile, and limited efficacy associated with anticancer drug development, the repositioning of established non-cancer drugs for new oncology indications has emerged as an increasingly attractive approach to addressing the unmet cancer-related medical need.
Mingkun, Jiao +3 more
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Challenges and opportunities of drug repositioning
Trends in Pharmacological Sciences, 2013Drug repositioning is an innovation stream of pharmaceutical development that offers advantages for drug developers along with safer medicines for patients. Several drugs have been successfully repositioned to a new indication, with the most prominent of them being viagra and thalidomide, which have generated historically high revenues.
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Drug Repositioning Using Computer-aided Drug Design (CADD)
Current Pharmaceutical BiotechnologyAbstract: Drug repositioning is a method of using authorized drugs for other unusually complex diseases. Compared to new drug development, this method is fast, low in cost, and effective. Through the use of outstanding bioinformatics tools, such as computer-aided drug design (CADD), computer strategies play a vital role in the re-transformation of ...
Sona, Rawat +12 more
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COVID-19 drugs and drug repositioning
2021Introduction: The COVID-19 pandemic is caused by SARS-CoV-2. Drug repositioning is a propitious field in the development and discovery of therapeutic agents that distinguishes new therapeutic options for existing drugs. There are repositioned drugs in COVID-19 treatment. Aim: We aimed to explore repositioned drugs for COVID-19 pharmacotherapy.
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
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Cancer epigenetics in clinical practice
Ca-A Cancer Journal for Clinicians, 2023Veronica Davalos, Manel Esteller
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