Results 61 to 70 of about 59,924 (341)
Turning genome-wide association study findings into opportunities for drug repositioning
Computational and Structural Biotechnology Journal, 2020 Drug development is a very costly and lengthy process, while repositioned or repurposed drugs could be brought into clinical practice within a shorter time-frame and at a much reduced cost.
Alexandria Lau, Hon-Cheong So
doaj +1 more source
Biomedicines, 2023 Drug repositioning offers the significant advantage of greatly reducing the cost and time of drug discovery by identifying new therapeutic indications for existing drugs.
Yoonbee Kim, Young-Rae Cho
doaj +1 more source
Drug prescription support in dental clinics through drug corpus mining [PDF]
, 2018 The rapid increase in the volume and variety of data poses a challenge to safe drug prescription for the dentist. The increasing number of patients that take multiple drugs further exerts pressure on the dentist to make the right decision at point-of ...
Goh, Wee Pheng +5 more
core +2 more sources
A neuronal network of mitochondrial dynamics regulates metastasis. [PDF]
, 2016 The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to localize
Aguinaldo, Angeline +14 more
core +3 more sources
Drug repositioning based on heterogeneous networks and variational graph autoencoders
Frontiers in Pharmacology, 2022 Predicting new therapeutic effects (drug repositioning) of existing drugs plays an important role in drug development. However, traditional wet experimental prediction methods are usually time-consuming and costly.
Song Lei, Xiujuan Lei, Lian Liu
doaj +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
DrugMechDB: A Curated Database of Drug Mechanisms
Scientific Data, 2023 Computational drug repositioning methods have emerged as an attractive and effective solution to find new candidates for existing therapies, reducing the time and cost of drug development.
Adriana Carolina Gonzalez-Cavazos +8 more
doaj +1 more source
A Review of Current In Silico Methods for Repositioning Drugs and Chemical Compounds
Frontiers in Oncology, 2021 Drug repositioning is a new way of applying the existing therapeutics to new disease indications. Due to the exorbitant cost and high failure rate in developing new drugs, the continued use of existing drugs for treatment, especially anti-tumor drugs ...
Binsheng He +5 more
doaj +1 more source
Advanced Functional Materials, EarlyView.This review explores functional and responsive materials for triboelectric nanogenerators (TENGs) in sustainable smart agriculture. It examines how particulate contamination and dirt affect charge transfer and efficiency. Environmental challenges and strategies to enhance durability and responsiveness are outlined, including active functional layers ...
Rafael R. A. Silva +9 more
wiley +1 more source
Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer
The Scientific World Journal, 2015 The goals of drug repositioning are to find a new pharmacological effect of a drug for which human safety and pharmacokinetics are established and to expand the therapeutic range of the drug to another disease. Such drug discovery can be performed at low
Kouji Banno +7 more
doaj +1 more source