Results 61 to 70 of about 26,660 (305)

GREP: genome for REPositioning drugs

Bioinformatics, 2019
Abstract Summary Making use of accumulated genetic knowledge for clinical practice is our next goal in human genetics. Here we introduce GREP (Genome for REPositioning drugs), a standalone python software to quantify an enrichment of the user-defined set of genes in the target of clinical indication ...
Sakaue, Saori, Okada, Yukinori
openaire   +2 more sources

Exploiting drug-disease relationships for computational drug repositioning [PDF]

Briefings in Bioinformatics, 2011
Finding new uses for existing drugs, or drug repositioning, has been used as a strategy for decades to get drugs to more patients. As the ability to measure molecules in high-throughput ways has improved over the past decade, it is logical that such data might be useful for enabling drug repositioning through computational methods.
Joel T, Dudley, Tarangini, Deshpande, Atul J, Butte   +2 more
openaire   +2 more sources

Spin and Charge Control of Topological End States in Chiral Graphene Nanoribbons on a 2D Ferromagnet

Advanced Materials, EarlyView.
Chiral graphene nanoribbons on a ferromagnetic gadolinium‐gold surface alloy display tunable spin and charge states at their termini. Atomic work function variations and exchange fields enabe transitions between singlet, doublet, and triplet configurations.
Leonard Edens, Francisco Romero‐Lara, Trisha Sai, Kalyan Biswas, Manuel Vilas‐Varela, Thomas Frederiksen, Diego Peña, Fabian Schulz, Jose Ignacio Pascual   +8 more
wiley   +1 more source

Untethered Magnetic Microswimmers for Targeted Particle Transport and Flow Manipulation

Advanced Materials Technologies, EarlyView.
This work introduces magnetically actuated microswimmers to dynamically reconfigure fluid flow within a single microfluidic device. Multiple homogeneous microswimmers are independently controlled by an external magnetic field to perform translational and rotational motions, thereby inducing real‐time flow manipulation.
Dineshkumar Loganathan, Dong‐Ming He, Kai‐Wei Chen, Chia‐Yuan Chen   +3 more
wiley   +1 more source

Potential Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions

Frontiers in Pharmacology, 2022
Gastric cancer (GC), second most leading cause of cancer-associated mortality globally, is the cancer of gastrointestinal tract in which malignant cells form in lining of the stomach, resulting in indigestion, pain, and stomach discomfort.
Md. Ataur Rahman, Md. Ataur Rahman, Md. Ataur Rahman, Kazi Rejvee Ahmed, MD. Hasanur Rahman, MD. Hasanur Rahman, Moon Nyeo Park, Moon Nyeo Park, Bonglee Kim, Bonglee Kim   +9 more
doaj   +1 more source

Drug Repositioning for COVID-19

Colombia Medica, 2020
Drug repositioning is a strategy that identifies new uses of approved drugs, to treat conditions different from their original purpose. With the advance of COVID-19 and the declaration of a pandemic; It has become the closest alternative to slow the advance of the virus. Antimalarial, antiviral drugs, antibiotics, glucocorticoids, monoclonal antibodies,
openaire   +4 more sources

Changing Trends in Computational Drug Repositioning [PDF]

Pharmaceuticals, 2018
Maximizing the indications potential and revenue from drugs that are already marketed offers a new take on the famous mantra of the Nobel Prize-winning pharmacologist, Sir James Black, “The most fruitful basis for the discovery of a new drug is to start with an old drug”.
Jaswanth K. Yella, Suryanarayana Yaddanapudi, Yunguan Wang, Anil G. Jegga   +3 more
openaire   +3 more sources

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Redefining Dendritic Cell Vaccines: Synergistically Co‐priming DC and B Cells With Nanoparticles Loading Whole Cell Antigens Maximizes the Efficacy of DC Vaccines

Advanced Science, EarlyView.
Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu, Xianlan Chen, Jin Wang, Yuhan Liu, Sidra Mustafa, Lu Diao, Rongrong Zhao, Haiyang Chi, Kang Hu, Jiashan Zhu, Jun Zhao, Mi Liu   +11 more
wiley   +1 more source

iDrug: Integration of drug repositioning and drug-target prediction via cross-network embedding.

PLoS Computational Biology, 2020
Computational drug repositioning and drug-target prediction have become essential tasks in the early stage of drug discovery. In previous studies, these two tasks have often been considered separately.
Huiyuan Chen, Feixiong Cheng, Jing Li
doaj   +1 more source