Results 91 to 100 of about 1,946,248 (285)

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules [PDF]

Pharmaceuticals, 2018
Schistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently relies on a single drug, praziquantel, and despite its efficacy against the all schistosome species that parasitize humans, it displays some problematic drawbacks and alone is ineffective in counteracting adverse pathologies associated with infection.
Maria João Gouveia, Paul J. Brindley, Fátima Gärtner, José M. Correia da Costa, Nuno Vale   +4 more
openaire   +4 more sources

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Trends in drug repurposing for chronic hepatitis-B infection: Bibliometric-based approach 1990-2024 [PDF]

BIO Web of Conferences
Chronic hepatitis B (CHB) infection is still a world problem today, especially in the developing countries. Until now, treatment related to CHB is still being continuously pursued using a variety of the latest approaches.
Irham Lalu Muhammad, Amukti Danang Prasetyaning, Adikusuma Wirawan, Singh Dilpreet, Chong Rockie, Pranata Satriya, Khairi Sabiah   +6 more
doaj   +1 more source

Machine Learning Applications in Drug Repurposing

, 2023
Fan Yang, Qi Zhang, Xiaokang Ji, Yanchun Zhang, Wentao Li, Shaoliang Peng, Fuzhong XueAbstractThe coronavirus disease (COVID-19) has led to an rush to repurpose existing drugs, although the underlying evidence base is of variable quality.
Interdis Sci Comp Life Sci (7335308)
core   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Computational repurposing of oncology drugs through off‐target drug binding interactions from pharmacological databases

Clinical and Translational Medicine
Purpose Systematic repurposing of approved medicines for another indication may accelerate drug development in oncology. We present a strategy combining biomarker testing with drug repurposing to identify new treatments for patients with advanced cancer.
Imogen R. Walpole, Farzana Y Zaman, Peinan Zhao, Vikki M. Marshall, Frank P. Lin, David M. Thomas, Mark Shackleton, Albert A. Antolin, Malaka Ameratunga   +8 more
doaj   +1 more source

Drug Repurposing Analyses in Polycystic Kidney Disease

, 2023
Code for PKD drug repurposing signature reversion analysis on publicly available ...
Ryan T. Brownlee, Jennifer L. Fisher, Vishal H. Oza, Timothy C. Howton, Brittany N. Lasseigne, Elizabeth J. Wilk   +5 more
core   +1 more source

Spatially Encoded Protocell Network for Non‐Cascaded Parallel Biocomputation

Advanced Science, EarlyView.
A non‐cascaded, hydrogel‐based proteinosome computational platform is developed, in which redox‐responsive proteinosomes serve as local computing units within a shared reaction–diffusion field. Reductant inputs, countered by an auxiliary glucose gradient, regulate spatially patterned proteinosome disruption, and generate population‐level boundaries ...
Shuqi Wu, Liangfei Tian
wiley   +1 more source

Drug repurposing for rare: progress and opportunities for the rare disease community

Frontiers in Medicine
Repurposing is one of the key opportunities to address the unmet rare diseases therapeutic need. Based on cases of drug repurposing in small population conditions, and previous work in drug repurposing, we analyzed the most important lessons learned ...
Anneliene Hechtelt Jonker, Anneliene Hechtelt Jonker, Daniel O’Connor, Daniel O’Connor, Maria Cavaller-Bellaubi, Maria Cavaller-Bellaubi, Christine Fetro, Christine Fetro, Maria Gogou, Maria Gogou, Peter A. C. ’T Hoen, Peter A. C. ’T Hoen, Martin de Kort, Martin de Kort, Heather Stone, Heather Stone, Nivedita Valentine, Nivedita Valentine, Anna Maria Gerdina Pasmooij, Anna Maria Gerdina Pasmooij   +19 more
doaj   +1 more source