Results 101 to 110 of about 3,841,835 (347)

Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study

Journal of Chemical Information and Modeling, 2020
The recent outbreak of novel coronavirus disease-19 (COVID-19) calls for and welcomes possible treatment strategies using drugs on the market. It is very efficient to apply computer-aided drug design techniques to quickly identify promising drug ...
Junmei Wang
semanticscholar   +1 more source

Rare Disease Drug Repurposing

JAMA Network Open
ImportanceTreatments are urgently needed for the more than 9500 rare diseases with no US Food and Drug Administration–approved therapies. Although repurposing can be less time- and cost-intensive compared with novel drug development, hurdles have impeded systematic repurposing.
Nijim, Sally, Korsunska, Ania, Zinski, Joseph, Bolden, Sarah E., Zuccato, Mary, Repasky, Mileva, Fajgenbaum, David C.   +6 more
openaire   +2 more sources

Degradable Magnetic Composites from Recycled NdFeB Magnets for Soft Actuation and Sensing

Advanced Robotics Research, EarlyView.
This work presents a degradable soft magnetic composite made from recycled NdFeB particles embedded in a gelatin‐based organogel. The material is processed into magnetic sensors and soft robotic components, which can later be dissolved in a green solvent to recover NdFeB magnetic particles.
Muhammad Bilal Khan, Lin Guo, Kilian Schäfer, Eduardo Sergio Oliveros‐Mata, Xiaotao Wang, Florian Hofmann, Matthias Lutzi, Mark Suppelt, Proloy Taran Das, Jan Schmidtpeter, Imants Dirba, Stephan Rinderknecht, Mario Kupnik, Denys Makarov, Oliver Gutfleisch   +14 more
wiley   +1 more source

The dark side of drug repurposing. From clinical trial challenges to antimicrobial resistance: analysis based on three major fields

Drug Target Insights
Drug repurposing is a strategic endeavor that entails the identification of novel therapeutic applications for pharmaceuticals that are already available in the market. Despite the advantageous nature of implementing this particular strategy owing to its
Majd M. Alsaleh, I. Natsheh, A. Alkhawaldeh, Duaa K. Albadawi, Maisa’ M. Darwish, M. Shammout   +5 more
semanticscholar   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Synthesize Heterogeneous Biological Knowledge via Representation Learning for Alzheimer's Disease Drug Repurposing

, 2022
Kang‐Lin Hsieh, Germán Plascencia‐Villa, Ko‐Hong Lin, George Perry, Xiaoqian Jiang, Yejin Kim   +5 more
openalex   +1 more source

TeX-Graph: Coupled tensor-matrix knowledge-graph embedding for COVID-19\n drug repurposing [PDF]

, 2020
Charilaos I. Kanatsoulis, Nicholas D. Sidiropoulos   +1 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Enhancing drug repurposing through graph neural networks and link prediction

, 2023
Lucia Prieto Santamaría, Adrián Ayuso-Muñoz, Alejandro Rodríguez‐González   +2 more
openalex   +1 more source

Drug repurposing for COVID-19: a potential threat of self-medication and controlling measures [PDF]

, 2020
Tauqeer Hussain Mallhi, Yusra Habib Khan, Nasser Hadal Alotaibi, Abdulaziz Ibrahim Alzarea, Abdullah Salah Alanazi, Sumera Qasim, Muhammad Shahid Iqbal, Nida Tanveer   +7 more
openalex   +1 more source