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Repurposing Drugs for Cancer Prevention
Current Topics in Medicinal Chemistry, 2016Development of agents for cancer prevention has been particularly challenging for two main reasons. One is the inherent difficulty in identifying targets for the heterogeneous group of processes that lead to invasive cancer arising at different target organ sites, while the other is the need for safe, tolerable interventions that can be given for ...
Daniel K, Lee, Eva, Szabo
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Repurposing Drugs for Cognition in Schizophrenia
Clinical Pharmacology & Therapeutics, 2016Currently approved treatments for schizophrenia only minimally affect the cognitive features of the illness that are the most closely related to disability. Hence, there is now considerable effort to repurpose drugs for schizophrenia, and to seek agents that can improve cognition by targeting receptor systems other than the dopaminergic system.
Y S, Yang, S R, Marder, M F, Green
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Drug repurposing in kidney disease
Kidney International, 2018Drug repurposing, is the re-tasking of known medications for new clinical indications. Advantages, compared to de novo drug development, include reduced cost and time to market plus the added benefit of a known pharmacokinetic and safety profiles. Suitable drug candidates are identified through serendipitous observations, data mining, or increased ...
Usha, Panchapakesan, Carol, Pollock
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Drug Repurposing for Drug Development in Stroke
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2010The development of new treatments for acute stroke has been fraught with costly and spectacularly disappointing failures. Repurposing of drugs already known to be safe provides a lower risk alternative. Investigators are using drug repurposing, in which marketed drugs are exploited for their secondary activity, to pursue agents that have multiple ...
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Repurposing of Drugs–The Ketamine Story
Journal of Medicinal Chemistry, 2020An intranasal formulation of esketamine, the S enantiomer of ketamine, in conjunction with an oral antidepressant, has been approved by the FDA for treating treatment-resistant major depressive disorder (TRD) in 2019, almost 50 years after it was approved as an intravenous anesthetic.
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Deep learning for drug repurposing: Methods, databases, and applications
Wiley Interdisciplinary Reviews: Computational Molecular Science, 2022Xiaoqin Pan, Xuan Lin, Dong-Sheng Cao
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Drug repurposing for fungal infections
The rise of multidrug-resistant bacteria is a well-recognized threat to world health, necessitating the implementation of effective treatments. This issue has been identified as a top priority on the global agenda by the World Health Organization. Certain strains, such as Candida glabrata, Candida krusei, Candida lusitaniae, Candida auris, select ...Anshu, Mathuria +3 more
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Drug repurposing for neurodegenerative diseases
Neurodegenerative diseases (NDDs) are neuronal problems that include the brain and spinal cord and result in loss of sensory and motor dysfunction. Common NDDs include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS) etc.Halak, Shukla +3 more
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Drug repurposing for respiratory infections
Respiratory infections such as Coronavirus disease 2019 are a substantial worldwide health challenge, frequently resulting in severe sickness and death, especially in susceptible groups. Conventional drug development for respiratory infections faces obstacles such as extended timescales, substantial expenses, and the rise of resistance to current ...Juveriya, Israr +2 more
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