Results 121 to 130 of about 1,830,783 (287)
CellsGynecological and obstetric infectious diseases are crucial to women’s health. There is growing evidence that links the presence of Fusobacterium nucleatum (F. nucleatum), an anaerobic oral commensal and potential periodontal pathogen, to the development
Arunita Ghosh +7 more
doaj +1 more source
Design for repurposing of composite products
, 2021 With the emerging demand for energy-efficient products, the composite material has become a point of attraction for many product manufacturers. Furthermore, with its high strength to weight ratio, long life span, low maintenance and design flexibility ...
Mehta, Parshva (author)
core
Advanced Science, EarlyView.Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li +10 more
wiley +1 more source
Advancing the human right to health in cancer care through drug repurposing strategies
International Journal for Equity in HealthThis perspective critically evaluates the global potential of drug repurposing strategies in oncology to advance health equity and sustainable innovation.
Nahida Sakis +3 more
doaj +1 more source
Drug Repurposing of New Treatments for Neuroendocrine Tumors
Drug repurposing or drug repositioning is the process of identifying new therapeutic uses for approved or investigational drugs beyond the original treatment indication.
Stefania Bellino +2 more
core +1 more source
Advanced Science, EarlyView.Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai +16 more
wiley +1 more source
Advanced Science, EarlyView.LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu +12 more
wiley +1 more source
Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation
Advanced Science, EarlyView.Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang +7 more
wiley +1 more source
International regulatory and publicly-funded initiatives to advance drug repurposing
Frontiers in MedicineIntroductionAlthough drug repurposing holds great potential in addressing unmet needs, successful practical implementation is challenging and has been less widespread than anticipated.
Eva Louise Spin +3 more
doaj +1 more source
Overcoming antibiotic resistance: the potential and pitfalls of drug repurposing
Since its emergence shortly after the discovery of penicillin, antibiotic resistance has escalated dramatically, posing a significant health threat and economic burden.
Khoshrou, Alireza +4 more
core +1 more source