Results 121 to 130 of about 1,946,248 (285)
CellsGynecological and obstetric infectious diseases are crucial to women’s health. There is growing evidence that links the presence of Fusobacterium nucleatum (F. nucleatum), an anaerobic oral commensal and potential periodontal pathogen, to the development
Arunita Ghosh +7 more
doaj +1 more source
Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy
Advanced Science, EarlyView.A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu +15 more
wiley +1 more source
Düzce Üniversitesi Bilim ve Teknoloji DergisiIn this study, research has been conducted using pre-trained knowledge graph embedding for drug repurposing in treating ALS (Amyotrophic Lateral Sclerosis), and its results have been presented.
Selcan Yalkızımı, Ümit Şentürk
doaj +1 more source
Insights into Computational Drug Repurposing for Neurodegenerative Disease [PDF]
, 2019 Computational drug repurposing has the ability to remarkably reduce drug development time and cost in an era where these factors are prohibitively high.
Marina Sirota +5 more
core +1 more source
Drug-disease networks and drug repurposing
PLOS Computational BiologyAbstract Repurposing existing drugs to treat new diseases is a cost-effective alternative to de novo drug development, but there are millions of potential drug-disease combinations to be considered with only a small fraction being viable.
Austin Polanco, Mark E. J. Newman
openaire +4 more sources
Advanced Science, EarlyView.Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin +7 more
wiley +1 more source
Research and analysis of regulatory framework and harmonisation of repurposing [PDF]
PharmaciaDrug repurposing is a modern and successful mechanism for discovering new therapeutic indications for authorised medicinal products. There is an absence of a clear definition of the term “drug repurposing” or its synonyms in regulatory frameworks, which ...
Antonio Ivanov +2 more
doaj +3 more sources
Overcoming antibiotic resistance: the potential and pitfalls of drug repurposing [PDF]
Since its emergence shortly after the discovery of penicillin, antibiotic resistance has escalated dramatically, posing a significant health threat and economic burden.
Khoshrou, Alireza +4 more
core +1 more source
Drug Repurposing Using Gene Expression Data Mining [PDF]
, 2023 The conventional drug discovery process that employs the one disease, one target, one drug\u27\u27 paradigm is expensive, time-consuming, and has a high rate of failure for multi-genic complex diseases.
Qiu, Yue
core
An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management
Advanced Science, EarlyView.Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer +12 more
wiley +1 more source