Results 221 to 230 of about 1,830,783 (287)

Therapeutic Potential of Ambroxol in Osteoarthritis: A Drug Repurposing Study. [PDF]

Pharmaceuticals (Basel)
Mesquita MJTAM, Cruz ACSND, Teixeira JTAMMM, Reis ATF, Frota GM, Carvalho TGPM, Carvalho RAF, Teixeira JAM, Andrade MS, Carvalho RC, Sousa EM, Sousa JCS, de Morais SV, Silva ER, Cartágenes MDSS, Garcia JBS.   +15 more
europepmc   +1 more source

Pectinase‐Based Bioprocesses for Circular Bioeconomy and Sustainable Industrial Development

Biotechnology and Bioengineering, EarlyView.
This picture demonstrates a unified strategy for sustainable pectinase production, focusing on microbial bioproduction, innovative strategies in enzyme engineering (Protein engineering, rational enzyme design, directed evolution and heterologous expression) and various applications in industry, including food, textiles, pulp and paper, agriculture and ...
Nisha Sharma, Dimple Tanwar, Usha Grewal, Murugesan Mohana Keerthi, Yogesh K. Ahlawat, Nitin Pandey, Chirag G. Makvana   +6 more
wiley   +1 more source

KG-bench: benchmarking graph neural network algorithms for drug repurposing. [PDF]

Bioinformatics
Wei S, Sasi C, Piepenbrock J, Huynen MA, 't Hoen PAC, SIMPATHIC Consortium.   +5 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Drug repurposing for glucosyltransferase inhibition for targeted oral biofilm disruption. [PDF]

NPJ Biofilms Microbiomes
de Lucena FS, Logan MG, Lewis SH, Zhang H, Barbisan M, Icimoto MY, Wu H, Higashi D, Merritt JL, Baker JL, Pfeifer CS.   +10 more
europepmc   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Toward clone‐on‐a‐chip: Ethical and legal considerations for organ‐on‐a‐chip evolution

BMEMat, EarlyView.
The term “clone‐on‐a‐chip (CoC)” is introduced as a conceptual warning for personalized organ‐on‐a‐chip platforms and not to suggest technological feasibility, where a CoC ethical discussion extends beyond issues arising from the requirements for informed consent, property rights, commercialization efforts, and cell sourcing to include potentially ...
Muhammed Erkan Karabekmez, Aliakbar Ebrahimi, Hamed Ghorbanpoor, Nicole Bassous, Su Ryon Shin, Yu Shrike Zhang, Huseyin Avci   +6 more
wiley   +1 more source

From Laboratory to Patient Access: A Scoping Review of the Multi-Dimensional Challenges in Drug Repurposing. [PDF]

Pharmacy (Basel)
Ivanov A, Ruseva V, Hababa-Ivanova I, Getova-Kolarova V, Lebanova H, Getov I.   +5 more
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Mapping the intellectual landscape of malaria drug repurposing: a systematic analysis of the 51 most cited studies. [PDF]

Malar J
Tizhe DT, Ogra IO, Adaji JZ, Usman S, Apeji YE, Kwaga JKP, Kia GSN, Sossou K.   +7 more
europepmc   +1 more source