Results 261 to 270 of about 3,896,424 (394)

Prompt-based multimodal representation learning for drug repurposing. [PDF]

Brief Bioinform
Liu J, U K, Rana D, Meixuan Zhang S, Yu J, Yang S, Jin B, Wang X, Yang Z, Tang H, Zhao J.   +10 more
europepmc   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, EarlyView.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Medicines, Diseases, Indications, and Contraindications (MeDIC): a foundational resource to support drug repurposing. [PDF]

Nucleic Acids Res
DeLuca M, Matentzoglu N, Sharp E, Li J, Hempstead C, Lim M, Kaniewski P, Carter EK, Koirala K, Ding E, Vijnck L, Brokmeier P, Toro S, Schaper K, Vergine J, Li O, Oprea TI, Fajgenbaum DC, Bizon C, Haendel M, Tropsha A.   +20 more
europepmc   +1 more source

Review of recent advances in the design, synthesis, and modification of biochar for remediation of heavy metal pollution in water

The Canadian Journal of Chemical Engineering, EarlyView.
Research frontiers in using biochar for heavy metal remediation. Abstract Heavy metal contamination of water has long been a serious environmental issue. Biochar and biochar‐based composites are emerging as effective and sustainable solutions for heavy metal removal due to their strong adsorption abilities and environmentally friendly nature.
Soumik Chakma, Mehedi Hasan, Sudip K. Rakshit, Janusz Kozinski, Kang Kang   +4 more
wiley   +1 more source

Targetable pathways for drug repurposing in gastric cancer. [PDF]

World J Gastroenterol
Valero-Almingol A, Montori S, Felípez N, Santamaría E, Fernandez-Irigoyen J, Luzko I, Cuestas AA, Pardo C, Prat R, Moreira L, Albéniz E.   +10 more
europepmc   +1 more source

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

Repurposing Drugs – Repurposing Diseases

Repurposing Drugs – Repurposing Diseases
openaire   +1 more source

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

Clinical Pharmacology &Therapeutics, EarlyView.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic, Deanne Nixie R. Miao, Britt I. Drögemöller, Alain Dabdoub, Julia M. Abitbol   +4 more
wiley   +1 more source

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
wiley   +1 more source

Exploiting similarity in drug molecular effects for drug repurposing. [PDF]

Hum Genomics
Huang K, Lalagkas PN, Sultan B, Melamed R.   +3 more
europepmc   +1 more source