Results 261 to 270 of about 3,841,835 (347)

Therapeutic Convergence in Neurodegeneration: Natural Products, Drug Repurposing, and Biomolecular Targets. [PDF]

Biomolecules
Vicidomini C, Roviello GN.
europepmc   +1 more source

The hidden regulators: Non‐coding RNAs in KMT2A‐rearranged acute lymphoblastic leukemia

International Journal of Cancer, EarlyView.
Abstract Acute lymphoblastic leukemia (ALL) driven by KMT2A rearrangements (KMT2A‐r) is an aggressive hematologic malignancy with poor prognosis and a high incidence in infants. While KMT2A fusion proteins drive leukemogenesis through transcriptional dysregulation, recent discoveries have highlighted the pivotal role of non‐coding RNAs (ncRNAs) in ...
Maria Augusta Poersch, Ana Carolina Rodrigues, Priscila Elias Ferreira Stricker, Alexandre Luiz Korte Azevedo, Daniel Pacheco Bruschi, Jaqueline Carvalho de Oliveira   +5 more
wiley   +1 more source

Network-Medicine-Guided Drug Repurposing for Alzheimer's Disease: A Multi-Dimensional Systems Pharmacology Approach. [PDF]

Int J Mol Sci
Akgüller Ö, Balcı MA, Cioca G.
europepmc   +1 more source

Exploring Potential for Repurposing Antiretroviral Drugs Etravirine and Efavirenz in Prostate and Bladder Cancer

Mariana Pereira, Nuno Vale
openalex   +1 more source

LIN‐24 as a Molecular Switch: Dual Cytotoxic and Cytoprotective Roles of an Aerolysin‐Like Protein in C. elegans

Journal of Applied Toxicology, EarlyView.
ABSTRACT LIN‐24, an aerolysin‐like pore‐forming protein in Caenorhabditis elegans, exemplifies how ancient cytolytic mechanisms have evolved into regulated cellular processes. Initially identified for inducing nonapoptotic, engulfment‐dependent cell death in vulval precursor cells, LIN‐24 has emerged as a multifunctional regulator of metabolism, stress
Sharoen Yu Ming Lim
wiley   +1 more source

Meta-Analysis and Topological Perturbation in Interactomic Network for Antiopioid Addiction Drug Repurposing. [PDF]

J Chem Inf Model
Zhang C, Cottrell S, Jones B, Zhu Y, Qiu H, Zhang B, Zhou T, Jiang J.   +7 more
europepmc   +1 more source

Optimizing rapeseed protein purification: a continuous chromatographic approach for napin and cruciferin

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Napin and cruciferin, the predominant storage proteins in Brassica napus (rapeseed), exhibit favorable techno‐functional properties such as emulsification and gel formation, positioning them as promising candidates for the encapsulation and delivery of bioactive compounds. Their classification as GRAS (Generally Recognized As Safe),
Jonas Arnecke, Jessica Gillmann, Tim Börner, Mathias Hafner, Christian Frech   +4 more
wiley   +1 more source

Carbon‐based materials from renewable sources: Challenges and perspectives with a focus on green coconut

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract This article presents a comprehensive examination of agricultural production, biomass generation, and its transformation into biochar, with a particular emphasis on green coconut waste as a primary resource. It underscores the link between agriculture and substantial biomass output, shedding light on the ecological issues associated with solid
Yslaine Andrade de Almeida, Iara de Fatima Gimenez, Ledjane Silva Barreto, Isis Nayra Rolemberg Prudente, Hericles Campos dos Santos   +4 more
wiley   +1 more source

Neural Vulnerabilities in Glioblastoma: Rethinking Therapy Through Neuroactive Drug Repurposing. [PDF]

Brain Tumor Res Treat
Colobon PO, Lee S.
europepmc   +1 more source