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Repurposing Drugs for Cancer Prevention
Current Topics in Medicinal Chemistry, 2016Development of agents for cancer prevention has been particularly challenging for two main reasons. One is the inherent difficulty in identifying targets for the heterogeneous group of processes that lead to invasive cancer arising at different target organ sites, while the other is the need for safe, tolerable interventions that can be given for ...
Daniel K, Lee, Eva, Szabo
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Repurposing Drugs for Cognition in Schizophrenia
Clinical Pharmacology & Therapeutics, 2016Currently approved treatments for schizophrenia only minimally affect the cognitive features of the illness that are the most closely related to disability. Hence, there is now considerable effort to repurpose drugs for schizophrenia, and to seek agents that can improve cognition by targeting receptor systems other than the dopaminergic system.
Y S, Yang, S R, Marder, M F, Green
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Drug Repurposing for Drug Development in Stroke
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2010The development of new treatments for acute stroke has been fraught with costly and spectacularly disappointing failures. Repurposing of drugs already known to be safe provides a lower risk alternative. Investigators are using drug repurposing, in which marketed drugs are exploited for their secondary activity, to pursue agents that have multiple ...
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Drug repurposing for neurodegenerative diseases
Neurodegenerative diseases (NDDs) are neuronal problems that include the brain and spinal cord and result in loss of sensory and motor dysfunction. Common NDDs include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS) etc.Halak, Shukla +3 more
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Drug repurposing for fungal infections
The rise of multidrug-resistant bacteria is a well-recognized threat to world health, necessitating the implementation of effective treatments. This issue has been identified as a top priority on the global agenda by the World Health Organization. Certain strains, such as Candida glabrata, Candida krusei, Candida lusitaniae, Candida auris, select ...Anshu, Mathuria +3 more
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2015
The aim of this discussion was to explore the concept and purpose of repositioning drugs, understand the boundaries that still underlie the technique and, analyze repurposed drugs, so they can serve of inspiration for the future of drug discovery and development.
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The aim of this discussion was to explore the concept and purpose of repositioning drugs, understand the boundaries that still underlie the technique and, analyze repurposed drugs, so they can serve of inspiration for the future of drug discovery and development.
openaire +1 more source
Recent advances in drug repurposing using machine learning
Current Opinion in Chemical Biology, 2021Puhl A C, Sean Ekins, Fabio Urbina
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Deep learning for drug repurposing: Methods, databases, and applications
Wiley Interdisciplinary Reviews: Computational Molecular Science, 2022Xuan Lin, Lifang He, Feixiong Cheng
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Drug repurposing for cancer therapy, easier said than done
Seminars in Cancer Biology, 2021Alfonso Duenas-Gonzalez +1 more
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Network medicine framework for identifying drug-repurposing opportunities for COVID-19
Proceedings of the National Academy of Sciences of the United States of America, 2021Xiao Gan +2 more
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