Results 271 to 280 of about 3,841,835 (347)

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou, Hao Jiang, Jingsheng Ruan, Daifeng Yang, Xing Chen, Shanshan Cai, Xinglin Yi   +6 more
wiley   +1 more source

Preliminary assessment of drug repurposing against virus-associated primary effusion lymphoma. [PDF]

J Microbiol Biol Educ
Plaza D, Chefitz G, McKiernan ER, Sandler SE, Levrero C, Kim K, Germano ER, Braner S, Ariyan LA, Miranda JL.   +9 more
europepmc   +1 more source

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

Computational Drug Repurposing Across the Multiple Myeloma Spectrum: From MGUS to MM. [PDF]

Cancers (Basel)
Savva K, Bourdakou MM, Stellas D, Zoidakis J, Spyrou GM.   +4 more
europepmc   +1 more source

Pharmacological MRI: Utility in Understanding Drug Mechanisms in Psychiatric Disorders

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Pharmacological MRI (pharmaMRI) has emerged as a powerful tool to study how psychoactive drugs affect brain function and to uncover mechanisms of drug action in psychiatric disorders. This review provides an overview of key techniques used in pharmaMRI, including BOLD‐fMRI, arterial spin labeling (ASL), and cerebral blood volume (CBV) mapping,
Christin Y. Sander, Tudor M. Ionescu, Mitul A. Mehta, Ottavia Dipasquale, Anouk Schrantee   +4 more
wiley   +1 more source

Network-based drug repurposing for psychiatric disorders using single-cell genomics. [PDF]

Cell Genom
Gupta C, Kalafut NC, Clarke D, Choi JJ, Arachchilage KH, Khullar S, Xia Y, Zhou X, Dursun C, Gerstein M, Wang D.   +10 more
europepmc   +1 more source

Ciprofloxacin Treatment in Juvenile Mice Involves Neuronal Activation and Mimics Physical Features of Human Disease

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Tendinopathy is a complex, painful condition that affects up to 5% of the general population in their lifetime. Antibiotic treatment with fluoroquinolones has been associated with the onset of tendinopathy and tendon rupture. The mechanisms behind fluoroquinolone induced tendinopathy remain unclear. To probe activation of potentially causative
Nicole A. Chittim, Amro A. Hussien, Nicolo Dubacher, Gabor Matyas, Jess G. Snedeker   +4 more
wiley   +1 more source

Integrative genomic and bioinformatic prioritization of drug repurposing candidates for prostate cancer. [PDF]

BMC Pharmacol Toxicol
Irham LM, Adikusuma W, Afief AR, Khairi S, Chong R, Mufidah S, Satria RD, Mugiyanto E, Darmawi D, Amukti DP, Wirsahada BC, Philothra PT, Jaya I.   +12 more
europepmc   +1 more source

Table 1_Computational drug repurposing in Parkinson’s disease: Omaveloxolone and cyproheptadine as promising therapeutic candidates.xlsx

Xin Guo (123593), Jie Wang (16762), Hongyang Fan (21014786), Wanying Tao (21014789), Zijing Ren (11661535), Xingyue Li (5168501), Suyu Liu (4480105), Peiyang Zhou (9180391), Yingzhu Chen (5564531)   +8 more
openalex   +1 more source