Results 31 to 40 of about 623,414 (303)
Nanoparticles for antiparasitic drug delivery
Drug Delivery, 2019 As an emerging novel drug carrier, nanoparticles provide a promising way for effective treatment of parasitic diseases by overcoming the shortcomings of low bioavailability, poor cellular permeability, nonspecific distribution and rapid elimination of ...
Yuzhu Sun +7 more
doaj +1 more source
Evaluation of Bioequivalence of Two Long-Acting 20% Oxytetracycline Formulations in Pigs
Frontiers in Veterinary Science, 2017 The aim of this study was to explore the bioequivalence of long-acting oxytetracycline in two formulations, a reference formulation (Terramycin 20% LA, Pfizer) and a test one (Kangtekang 20% LA, Huishen).
Jiyue Cao +8 more
doaj +1 more source
Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows [PDF]
, 2017 We describe a computational protocol to aid the design of small molecule and peptide drugs that target protein-protein interactions, particularly for anti-cancer therapy. To achieve this goal, we explore multiple strategies, including finding binding hot
A Goncearenco +44 more
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Influenza A nucleoprotein binding sites for antivirals: current research and future potential [PDF]
, 2014 This document is the Accepted Manuscript version of the following article: Andreas Kukol and Hershna Patel, ‘Influenza A nucleoprotein binding sites for antivirals: current research and future potential’, Future Biology, Vol 9(7): 625-627, July 2014. The
Kukol, A, Kukol, A, Patel, H., Patel, H.
core +2 more sources
Structure-activity relationships of fluorene compounds inhibiting HCV variants [PDF]
, 2020 Approximately 71 million people suffer from hepatitis C virus (HCV) infection worldwide. Persistent HCV infection causes liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, resulting in approximately 400,000 deaths ...
Gadhe, Changdev G. +10 more
core +1 more source
Phage Products for Fighting Antimicrobial Resistance
Microorganisms, 2022 Antimicrobial resistance (AMR) has become a global public health issue and antibiotic agents have lagged behind the rise in bacterial resistance. We are searching for a new method to combat AMR and phages are viruses that can effectively fight bacterial ...
Yuanling Huang +6 more
doaj +1 more source
Antibiotics and Drugs: Residue Determination [PDF]
, 2016 Veterinary drugs pose a real risk to human health if their residues are allowed to enter the food chain. Parent drugs and their metabolites can occur in foodstuffs individually or as multicomponent mixtures with enhanced adverse effects. In order to protect the safety of the consumers, the European Union has established lists of forbidden substances ...
Gentili, Alessandra +3 more
openaire +2 more sources
Allo-network drugs: Extension of the allosteric drug concept to protein-protein interaction and signaling networks [PDF]
, 2013 Allosteric drugs are usually more specific and have fewer side effects than orthosteric drugs targeting the same protein. Here, we overview the current knowledge on allosteric signal transmission from the network point of view, and show that most ...
Csermely, Péter +2 more
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Drug Delivery, 2022 In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by ...
Zhiwei Liang, Dongmei Chen
doaj +1 more source
Molecular Dynamics Studies on HIV-1 Protease: Drug Resistance and Folding Pathways [PDF]
, 2001 Drug resistance to HIV-1 Protease involves accumulation of multiple mutations in the protein. Here we investigate the role of these mutations by using molecular dynamics simulations which exploit the influence of the native-state topology in the folding ...
Carloni, Paolo +3 more
core +2 more sources