DNA Origami‐Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity
Aptamers displayed on tubular DNA origami nanostructures in defined chiral orientations (left‐ or right‐handed) exhibit enantioselective interactions with cell surface target proteins. While the right‐handed configuration supports only transient binding, the left handedness energetically favors protein dimerization and promotes subsequent ...
Tingjie Song +9 more
wiley +1 more source
Treating Extensively Drug-Resistant Acinetobacter baumannii: Considerations for Host Characteristics and Type of Infections. [PDF]
Geladari A +9 more
europepmc +1 more source
Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis
This study identifies a “mechano‐epigenetic” checkpoint in which matrix stiffness governs the immune responses of gingival fibroblasts. Using biomimetic hydrogels and human gingival explants, the studies revealed that restoring extracellular matrix stiffness actively suppresses inflammation via non‐canonical NF‐κB signaling and DNA methylation ...
Hardik Makkar +5 more
wiley +1 more source
Targeting Bacterial Cell Wall Synthesis: Structural Insights and Emerging Therapeutic Strategies. [PDF]
Sanapalli BKR, Jones CR, Sanapalli V.
europepmc +1 more source
[Multi-drug resistant bacterial infections].
A, Ono, K, Yamaguchi
openaire +1 more source
Materials and System Design for Self‐Decision Bioelectronic Systems
This review highlights how self‐decision bioelectronic systems integrate sensing, computation, and therapy into autonomous, closed‐loop platforms that continuously monitor and treat diseases, marking a major step toward intelligent, self‐regulating healthcare technologies.
Qiankun Zeng +9 more
wiley +1 more source
Antimicrobial Resistance Profiles of Bacterial Conjunctivitis Isolates from a Secondary Hospital in Shanghai: A 5-Year Retrospective Study (2020-2024). [PDF]
Xu W +6 more
europepmc +1 more source
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton +2 more
wiley +1 more source
Nanovesicular Drug Delivery Systems for Overcoming Antibiotic Resistance. [PDF]
Pillai G, Jankie S.
europepmc +1 more source
xx xx. ABSTRACT Diabetic foot ulcer (DFU) is a chronic complication of diabetes, primarily caused by hyperglycemia, peripheral vascular disease, and neuropathy. Characterized by persistent hyperglycemia, impaired perfusion, inflammation, and infection, DFUs pose significant challenges to healing and are associated with high morbidity and amputation ...
Tang Yuqing +5 more
wiley +1 more source

