Results 111 to 120 of about 613,359 (339)
Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance
Journal of Fungi, 2020 Although polyenes were the first broad spectrum antifungal drugs on the market, after 70 years they are still the gold standard to treat a variety of fungal infections. Polyenes such as amphotericin B have a controversial image.
Hans Carolus +3 more
semanticscholar +1 more source
Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis
Advanced Science, EarlyView.This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen +7 more
wiley +1 more source
MBX-7591: a promising drug candidate against drug-resistant fungal infections
mBioABSTRACT Invasive fungal infections (IFIs) caused by pathogenic fungi pose a significant public health concern, particularly for immunocompromised individuals. Mortality rates for IFIs remain high, and currently available treatment options are limited.
Nivea Pereira de Sa, Maurizio Del Poeta
openaire +3 more sources
Advanced Science, EarlyView.Utilizing molecular engineering for network design, three pesticide‐loaded organogels (PLOs) carriers exhibiting varying degrees of flexibility were prepared. The mechanical properties of these carriers, tunable via their network molecular structures, enhance their structural adaptability and retention stability at biological interfaces, thereby ...
Yue Wang +6 more
wiley +1 more source
F1000Research, 2017 Background: Candida infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden of HIV co-infection.
Charlene Wilma Joyce Africa +1 more
doaj +1 more source
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
F1000Research, 2016 Background: Candida infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden of HIV co-infection.
Charlene Wilma Joyce Africa +1 more
doaj +1 more source
Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action. [PDF]
, 2018 Bioactive natural products have evolved to inhibit specific cellular targets and have served as lead molecules for health and agricultural applications for the past century1-3.
Bat-Erdene, Undramaa +9 more
core
Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes [PDF]
, 2014 Copyright © 2014 Kaloriti et al.Peer reviewedPublisher ...
Bohovych, Iryna +15 more
core +2 more sources
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
Nature Communications, 2020 The frequency of antifungal resistance, particularly to the azole class of ergosterol biosynthetic inhibitors, is a growing global health problem. Survival rates for those infected with resistant isolates are exceptionally low. Beyond modification of the
Takanori Furukawa +22 more
semanticscholar +1 more source