Results 141 to 150 of about 543,044 (334)

Controllable Generation of Pathogen‐Specific Antimicrobial Peptides Through Knowledge‐Aware Prompt Diffusion Model

Advanced Science, EarlyView.
KPPepGen is a knowledge‐aware prompt diffusion model for the controllable generation of pathogen‐specific AMPs. It outperforms existing methods and is capable of simultaneously generating peptides for distinct pathogens, demonstrating superior performance with favorable properties and docking efficacy.
Yongkang Wang, Menglu Li, Feng Huang, Minyao Qiu, Wen Zhang   +4 more
wiley   +1 more source

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

Advanced Science, EarlyView.
The artificial biosynthetic pathway potentially involved in biosynthesis of enfumafungin is first reconstructed in an optimized Aspergillus oryzae chassis with the increased site‐specific integration efficiency and shortened time for marker recycling, which requires an artificial fusion enzyme EfuA(TC)FsoA(GT).
Yaohui Gao, Jianming Lv, Yue Zhong, Zhiqin Cao, Rui Luo, Yue Qi, Gaoqian Wang, Shaoyang Li, Guodong Chen, Dan Hu, Hao Gao, Xinsheng Yao   +11 more
wiley   +1 more source

Biofilm formation and drug susceptibility of biofilm Candida spp. clinically isolated from nasopharyngeal cancer patients in Vietnam

Iranian Journal of Microbiology
Background and Objectives: The biofilm formation has been widely recognized as one of the main mechanisms of antimicrobial resistance development in microorganisms. However, few studies are focusing on this phenomenon in Candida spp.
Bac Vu Giang Nguyen, Linh Xuan Thi Tran, Thanh-Hoa Vo, Anh-Tu Nguyen-Ha, Minh-Tri Le, Phuoc-Vinh Nguyen   +5 more
doaj   +1 more source

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

Advanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim, Si Hyeon Chae, Dahae Lee, Bum Soo Lee, Jiseok Lim, Hyo‐Il Jung, Ki Hyun Kim, Bongseop Kwak   +7 more
wiley   +1 more source

Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin‐mediated Phagocytic Effects for Lung Cancer Treatment

Advanced Science, EarlyView.
Repurposing cardiac glycosides (CGs) significantly strengthens the efficacy of anti‐CD47 antibody for lung cancer treatment by boosting macrophage phagocytosis. This novel combination blocks the “don't eat me” signal and increases dual “eat‐me” signals, Fc‐FcγR and cell surface expression of calreticulin (ecto‐CRT).
Zi‐Han Ye, Wei‐Bang Yu, Mu‐Yang Huang, Yan‐Yan Chen, Le‐Le Zhang, Chung‐Hang Leung, Xiao‐Lei Zhang, Zhenghai Tang, Ting Li, Jin‐Jian Lu   +9 more
wiley   +1 more source

Update on the Fungal Biofilm Drug Resistance and Its Alternative Treatment

Journal of Biosciences and Medicines, 2016
Candida albicans (C. albicans) and Aspergillus fumigatus (A. fumigatus) are the two main pathogens in the clinical setting to cause serious, sometimes, lethal fungal infections. Immunocompromised patients fall victims to these fungi, with a mortality rate rising drastically over the past decades.
Jingjun Zhao, Karina Siow Yen Ng How Tseung   +1 more
openaire   +3 more sources

Transcriptional control of drug resistance, virulence and immune system evasion in pathogenic fungi: a cross-species comparison.

Frontiers in Cellular and Infection Microbiology, 2016
Transcription factors are key players in the control of the activation or repression of gene expression programs in response to environmental stimuli. The study of regulatory networks taking place in fungal pathogens is a promising research topic that ...
Pedro Pais, Pedro Pais, Catarina Costa, Catarina Costa, Mafalda Cavalheiro, Mafalda Cavalheiro, Daniela Romão, Daniela Romão, Miguel Cacho Teixeira, Miguel Cacho Teixeira   +9 more
doaj   +1 more source

Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization

Advanced Science, EarlyView.
Molecular glues that stabilize protein–protein interactions are challenging to identify. Here, hydrogen‐deuterium exchange mass spectrometry can show and reveal gluing mechanisms that vary between protein binding partners. Abstract Molecular glues are powerful bioactive molecules that stabilize protein–protein interactions.
Danielle F. Kay, Hadeeqa G. Raza, Richard G. Doveston, Aneika C. Leney   +3 more
wiley   +1 more source

Global emergence of a multi-drug resistant fungal pathogen,Candida auris

Southern African Journal of Infectious Diseases, 2016
No abstract available.
Erika Britz, Nelesh P. Govender
openaire   +4 more sources

Identification of a Pair of Linear or Cyclic Naturally Inspired Bifunctional Lipopeptide Antibiotics That Overcome Antimicrobial Resistance

Advanced Science, EarlyView.
The underexplored bacterial genus Aquimarina harbors a large biosynthetic potential for discovering new antibiotics. Here, the authors identify a pair of linear or cyclic bifunctional cationic lipopeptide antibiotics, aquicidine L and C4, inspired by the aquicidine gene cluster from Aquimarina.
Lei Li, Yiwen Zhou, Yuzhu Wu
wiley   +1 more source