Results 251 to 260 of about 160,880 (298)
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Elucidating Drug Resistance in Human Fungal Pathogens
Future Microbiology, 2014Fungal pathogens cause life-threatening infections in immunocompetent and immunocompromised individuals. Millions of people die each year due to fungal infections, comparable to the mortality attributable to tuberculosis or malaria. The three most prevalent fungal pathogens are Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus.
Jinglin Lucy, Xie +3 more
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Experimental evolution of drug resistance in human fungal pathogens
Current Opinion in Genetics & Development, 2022Experimental evolution in vitro is a powerful tool to uncover the factors that contribute to resistance evolution and understand the genetic basis of adaptation. Here, we discuss recent experimental evolution studies from human fungal pathogens. We synthesize the results to highlight the common threads that influence resistance acquisition. The picture
Aleeza C, Gerstein, Parul, Sethi
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INTRAVITREAL VORICONAZOLE FOR DRUG-RESISTANT FUNGAL ENDOPHTHALMITIS
Retina, 2006To report the efficacy of intravitreal voriconazole.Retrospective analysis of an interventional case series of five cases of culture-proven fungal endophthalmitis treated with intravitreal voriconazole was done. Only cases found to be resistant to conventional antifungal agents were included in the study.
Parveen, Sen +2 more
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Sphingolipids: Regulators of azole drug resistance and fungal pathogenicity
Molecular Microbiology, 2020AbstractIn recent years, the role of sphingolipids in pathogenic fungi, in terms of pathogenicity and resistance to azole drugs, has been a rapidly growing field. This review describes evidence about the roles of sphingolipids in azole resistance and fungal virulence.
Jinxing Song, Xiao Liu, Rongpeng Li
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Fungal Drug Resistance: Azoles
2009Azole antifungal agents are widely used in the clinical arena to treat a variety of fungal infections. The azoles inhibit fungal lanosterol demethylase, a key fungal enzyme in the ergosterol biosynthetic pathway, leading to an altered membrane physiology and, most frequently, a fungistatic effect.
Jose L. Lopez-Ribot, Thomas F. Patterson
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2009
The increase in opportunistic mycosis as well as the emergence of antifungal resistance and the development of novel antifungal drugs necessitated the development of standard phenotypic drug resistance assays for fungi. Microdilution methods for testing yeasts (CLSI M27-A3 and EUCAST E.Def 7.2 assay) and filamentous fungi (CLSI M38-A2 and EUCAST E.Def ...
Sevtap Arikan, John H. Rex
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The increase in opportunistic mycosis as well as the emergence of antifungal resistance and the development of novel antifungal drugs necessitated the development of standard phenotypic drug resistance assays for fungi. Microdilution methods for testing yeasts (CLSI M27-A3 and EUCAST E.Def 7.2 assay) and filamentous fungi (CLSI M38-A2 and EUCAST E.Def ...
Sevtap Arikan, John H. Rex
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Learning the
SummaryATP‐binding cassette (ABC) proteins are ubiquitous in prokaryotes and eukaryotes. They are involved in energy‐dependent transport of molecules across membranes. ABC proteins are often promiscuous transporters that can translocate a variety of substrates.
R D, Cannon, A R, Holmes
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Fungal Biofilms: Agents of Disease and Drug Resistance
2014Bacterial biofilms and their role in disease have been investigated in detail over 15 to 20 years, but research on fungal biofilms has traditionally lagged. Although other fungal species have been associated with biofilm formation, this chapter concentrates on Candida albicans since it is the fungal system that has received the most attention to date ...
Ramage, Gordon +2 more
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