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Biomimetic Nanopillared Surfaces Inhibit Drug Resistant Filamentous Fungal Growth
ACS Applied Bio Materials, 2019Filamentous fungi are invasive and multidrug resistant pathogens that commonly contaminate biomedical devices and implants. Once spherical fungal spores attach to a surface, they exhibit germ tube development, hyphal growth, and robust biofilm formation.
Rachel Rosenzweig +5 more
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Antifungal Drug Resistance of Dermatophytes Causing Superficial Fungal Infections
The Journal of Sylhet Women’s Medical College, 2022Background: Superficial fungal infections (SFI) are common skin diseases that were largely simple to treat. However, due to increasing antimicrobial resistance (AMR) of dermatophytes to antifungal drugs, treatment of SFI has become difficult. This study aims to analyze the AMR of dermatophytes and to correlate with the clinical response of antifungal ...
null Chowdhury PA +4 more
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Resistance of human fungal pathogens to antifungal drugs
Current Opinion in Microbiology, 2002Resistance mechanisms can be engaged in clinically relevant fungal pathogens under different conditions when exposed to antifungal drugs. Over past years, active research was undertaken in the understanding of the molecular basis of antifungal drug resistance in these pathogens, and especially against the class of azole antifungals.
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Emerging Virulence, Drug Resistance and Future Anti-fungal Drugs for Candida Pathogens
Current Topics in Medicinal Chemistry, 2018Increased incidences of Candida infection have augmented morbidity and mortality in human population, particularly among severely immunocompromised patients and those having a long stay in hospitals (nosocomial infections). Many virulence factors and fitness attributes are reported to be associated with the pathogenicity of Candida sp.
Vartika, Srivastava +2 more
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Human Fungal Pathogens and Drug Resistance Against Azole Drugs
2017Pathogenic fungi causing severe infections in humans with immunocompromised immune system have been the major reasons of deaths in the world. Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus are among the most prevalent human fungal pathogens. The most widely used therapy used for the invasive fungal infections is the treatment with
Preetida J. Bhetariya +5 more
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Role of Mitochondria in Fungal Drug Resistance
2019Incidences of opportunistic fungal infections and related mortality are growing threats to immunosuppressed patients. Limited arsenal in form of antifungals, along with emerging resistance, their toxicity and efficacy are the bottlenecks in successful treatment.
Ritu Pasrija, Deepika Kundu
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Pathogenesis of Fungal Infections and Drug-Resistance Phenomenon
2020Fungi the primitive eukaryotes are emerging as life-threatening pathogens of public health. Over a decade and ago, the frequency of fungal infections has been enormous, with an increased range of mortality and morbidity in immunocompromised patients.
Sudhakar Pola +3 more
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Fungal ATP-Binding Cassette (ABC) Transporters in Drug Resistance & Detoxification
Current Drug Targets, 2006Pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi. PDR shares several similarities with processes in bacteria and higher eukaryotes. In mammalian cells, multidrug resistance (MDR) develops from an initial single drug resistance, eventually leading to a broad cross-resistance to many structurally and functionally ...
György, Sipos, Karl, Kuchler
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Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification
Research in Microbiology, 2001A number of prominent genetic diseases are caused by mutations in genes encoding ATP-binding cassette (ABC) proteins (Ambudkar, Gottesmann, 1998). Moreover, several mammalian ABC proteins such as P-glycoprotein (P-gp) (Gottesman et al., 1995) and multidrug-resistance-associated proteins (MRPs) (Cole, Deeley, 1998) have been implicated in multidrug ...
H, Wolfger, Y M, Mamnun, K, Kuchler
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
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