Results 281 to 290 of about 4,538,104 (325)
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Learning the ABC of oral fungal drug resistance.
Molecular Oral Microbiology, 2015SummaryATP‐binding cassette (ABC) proteins are ubiquitous in prokaryotes and eukaryotes. They are involved in energy‐dependent transport of molecules across membranes. ABC proteins are often promiscuous transporters that can translocate a variety of substrates.
R. Cannon, A. R. Holmes
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Experimental evolution of drug resistance in human fungal pathogens
Current Opinion in Genetics & Development, 2022Experimental evolution in vitro is a powerful tool to uncover the factors that contribute to resistance evolution and understand the genetic basis of adaptation. Here, we discuss recent experimental evolution studies from human fungal pathogens. We synthesize the results to highlight the common threads that influence resistance acquisition. The picture
Aleeza C, Gerstein, Parul, Sethi
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Elucidating drug resistance in human fungal pathogens.
Future Microbiology, 2014Fungal pathogens cause life-threatening infections in immunocompetent and immunocompromised individuals. Millions of people die each year due to fungal infections, comparable to the mortality attributable to tuberculosis or malaria. The three most prevalent fungal pathogens are Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus.
Jinglin L. Xie +3 more
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Fungal Drug Resistance: Azoles
2009Azole antifungal agents are widely used in the clinical arena to treat a variety of fungal infections. The azoles inhibit fungal lanosterol demethylase, a key fungal enzyme in the ergosterol biosynthetic pathway, leading to an altered membrane physiology and, most frequently, a fungistatic effect.
Jose L. Lopez-Ribot, Thomas F. Patterson
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Emerging Role of Sphingolipids in Amphotericin B Drug Resistance
Microbial Drug Resistance, 2023Invasive fungal infections in humans are common in people with compromised immune systems and are difficult to treat, resulting in high mortality. Amphotericin B (AmB) is one of the main antifungal drugs available to treat these infections.
Kashish Madaan, V. Bari
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2009
The increase in opportunistic mycosis as well as the emergence of antifungal resistance and the development of novel antifungal drugs necessitated the development of standard phenotypic drug resistance assays for fungi. Microdilution methods for testing yeasts (CLSI M27-A3 and EUCAST E.Def 7.2 assay) and filamentous fungi (CLSI M38-A2 and EUCAST E.Def ...
ARIKAN AKDAĞLI, SEVTAP, Rex, John H.
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The increase in opportunistic mycosis as well as the emergence of antifungal resistance and the development of novel antifungal drugs necessitated the development of standard phenotypic drug resistance assays for fungi. Microdilution methods for testing yeasts (CLSI M27-A3 and EUCAST E.Def 7.2 assay) and filamentous fungi (CLSI M38-A2 and EUCAST E.Def ...
ARIKAN AKDAĞLI, SEVTAP, Rex, John H.
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The impact of phenotypic heterogeneity on fungal pathogenicity and drug resistance
FEMS Microbiology ReviewsAbstract Phenotypic heterogeneity in genetically clonal populations facilitates cellular adaptation to adverse environmental conditions while enabling a return to the basal physiological state. It also plays a crucial role in pathogenicity and the acquisition of drug resistance in unicellular organisms and cancer cells, yet the exact ...
Judith Berman, Lukasz Kozubowski
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Fungal Biofilms: Agents of Disease and Drug Resistance
2014Bacterial biofilms and their role in disease have been investigated in detail over 15 to 20 years, but research on fungal biofilms has traditionally lagged. Although other fungal species have been associated with biofilm formation, this chapter concentrates on Candida albicans since it is the fungal system that has received the most attention to date ...
Ramage, Gordon +2 more
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Resistance of human fungal pathogens to antifungal drugs
Current Opinion in Microbiology, 2002Resistance mechanisms can be engaged in clinically relevant fungal pathogens under different conditions when exposed to antifungal drugs. Over past years, active research was undertaken in the understanding of the molecular basis of antifungal drug resistance in these pathogens, and especially against the class of azole antifungals.
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INTRAVITREAL VORICONAZOLE FOR DRUG-RESISTANT FUNGAL ENDOPHTHALMITIS
Retina, 2006To report the efficacy of intravitreal voriconazole.Retrospective analysis of an interventional case series of five cases of culture-proven fungal endophthalmitis treated with intravitreal voriconazole was done. Only cases found to be resistant to conventional antifungal agents were included in the study.
Parveen, Sen +2 more
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