Results 291 to 300 of about 4,538,104 (325)

Role of Mitochondria in Fungal Drug Resistance

2019
Incidences of opportunistic fungal infections and related mortality are growing threats to immunosuppressed patients. Limited arsenal in form of antifungals, along with emerging resistance, their toxicity and efficacy are the bottlenecks in successful treatment.
Ritu Pasrija, Deepika Kundu
openaire   +1 more source

Pathogenesis of Fungal Infections and Drug-Resistance Phenomenon

2020
Fungi the primitive eukaryotes are emerging as life-threatening pathogens of public health. Over a decade and ago, the frequency of fungal infections has been enormous, with an increased range of mortality and morbidity in immunocompromised patients.
Sudhakar Pola, Akella Vijayaramya, Pavani Sanapala, V. A. Iswarya Deepthi   +3 more
openaire   +1 more source

Human Fungal Pathogens and Drug Resistance Against Azole Drugs

2017
Pathogenic fungi causing severe infections in humans with immunocompromised immune system have been the major reasons of deaths in the world. Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus are among the most prevalent human fungal pathogens. The most widely used therapy used for the invasive fungal infections is the treatment with
Preetida J. Bhetariya, Neha Sharma, Pragati Singh, Priyanka Tripathi, Santosh K. Upadhyay, Poonam Gautam   +5 more
openaire   +1 more source

Drug resistance mechanisms of fungal biofilms

2011
Fungi are ubiquitous in nature and exist in soil, water, plants, and in animals andhumans. Similar to bacteria, fungi also form confluent biofilms either singly (monospecies)or with other microbial species (mixed-species). Fungal biofilms are known tobe highly resistant to the adverse environmental conditions including antimicrobials andbiocide ...
Seneviratne, C. Jayampath, Samaranayake, Lakshman P.   +1 more
openaire   +1 more source

Combating Fungal Infections and Resistance with a Dual-Mechanism Luminogen to Disrupt Membrane Integrity and Induce DNA Damage.

Journal of the American Chemical Society
Antifungal drug resistance is a critical concern, demanding innovative therapeutic solutions. The dual-targeting mechanism of action (MoA), as an effective strategy to reduce drug resistance, has been validated in the design of antibacterial agents ...
Xianglong Liu, Hao Li, Guobin Qi, Yunyun Qian, Bo-Wen Li, Leilei Shi, Bin Liu   +6 more
semanticscholar   +1 more source

Drug development challenges and strategies to address emerging and resistant fungal pathogens

Expert Review of Anti-infective Therapy, 2017
Invasive fungal infections represent an expanding threat to public health. The recent emergence of Candida auris, which is often resistant to existing antifungal agents and is associated with a high mortality rate, underscores the urgent need for novel drug development strategies.
Matthew W, McCarthy, Thomas J, Walsh
openaire   +2 more sources

In the Crossroad Between Drug Resistance and Virulence in Fungal Pathogens

2018
Fungal species from the Cryptococcus, Candida, and Aspergillus genera are recognized as important human pathogens, causing infections which are often deadly and extremely difficult to treat due to their ability to exhibit and develop antifungal resistance and virulence.
Mafalda Cavalheiro, Miguel Cacho Teixeira   +1 more
openaire   +1 more source

The race to beat deadly, drug-resistant fungal diseases

Open Access Government
The race to beat deadly, drug-resistant fungal diseases Professors Elaine Bignell and Neil A.R. Gow address the growing threat of fungal infections, highlighting the sharp rise in drug-resistant cases, and the required efforts to better understand and mitigate fAMR. Fungi are agents of mass crop destruction, but
Elaine Bignell, Neil A R Gow
openaire   +1 more source

Resistance and tolerance mechanisms to antifungal drugs in fungal pathogens

Mycologist, 2003
Fungal pathogens are using several mechanisms to circumvent the inhibitory actions of antifungal drugs. The variety of these mechanisms was revealed in recent years by several laboratories with molecular approaches. Besides the identification of genes involved in antifungal drug resistance and the discovery of alternative pathways of resistance (i.e ...
openaire   +1 more source

- Molecular Characterization of Fungal Drug Resistance

2011
Maurizio Sanguinetti, Brunella Posteraro, Patrizia Posteraro   +2 more
openaire   +2 more sources