Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles
Mass Spectrometry Reviews, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág +5 more
wiley +1 more source
Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics
Mass Spectrometry Reviews, EarlyView.ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers +5 more
wiley +1 more source
Baicalein suppresses adhesion and biofilm formation in <i>Candida auris</i>. [PDF]
Microbiol SpectrLi C +7 more
europepmc +1 more source
Senotherapeutics for Knee Osteoarthritis
Medicinal Research Reviews, EarlyView.ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman +6 more
wiley +1 more source
Repeated Spontaneous Transurethral Passage of Urinary Fungal Masses Associated with <i>Candida tropicalis</i> Candiduria in a Diabetic Patient with Multiple Urinary Calculi: A Case Report. [PDF]
Infect Drug ResistNiu S, Li T, Liu F.
europepmc +1 more source
Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance
Medicinal Research Reviews, EarlyView.ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi +4 more
wiley +1 more source
A full review of online education resources available on antifungal stewardship. [PDF]
JAC Antimicrob ResistAbraham K +4 more
europepmc +1 more source
Decoding Molecular Mechanisms of Pongamia pinnata Phytochemicals in Cancer Therapy
Medicine Advances, EarlyView.Pongamia pinnata phytochemicals have multiple anticancer mechanisms, including antioxidant, anti‐inflammatory, anti‐metastatic, and apoptosis‐inducing activities through molecular‐level regulation. These bioactive compounds protect normal cells from oxidative stress while promoting reactive oxygen species‐mediated tumor cell death and suppressing ...
Rajib Dhar, Vetriselvan Subramaniyan
wiley +1 more source
In vitro antimicrobial potential and phytochemical analysis of root extracts of Rumex abyssinicus from southern Ethiopia. [PDF]
PLoS OneAmeya G +4 more
europepmc +1 more source
Harnessing plant susceptibility genes into strategies for enhanced disease resistance
New Plant Protection, EarlyView.Integrated model of S gene modules in plant pathogen interactions. This model summarises representative host susceptibility modules that can be exploited by bacterial, fungal and viral pathogens. In the bacterial infection module, Xanthomonas transcription activator‐like effectors activate OsSWEET14 through effector‐binding elements in its promoter ...
Can Chen +4 more
wiley +1 more source