Results 251 to 260 of about 84,689 (291)

Sphingolipids: Regulators of azole drug resistance and fungal pathogenicity

Molecular Microbiology, 2020
AbstractIn recent years, the role of sphingolipids in pathogenic fungi, in terms of pathogenicity and resistance to azole drugs, has been a rapidly growing field. This review describes evidence about the roles of sphingolipids in azole resistance and fungal virulence.
Jinxing Song, Xiao Liu, Rongpeng Li
openaire   +2 more sources

The impact of phenotypic heterogeneity on fungal pathogenicity and drug resistance

FEMS Microbiology Reviews
Abstract Phenotypic heterogeneity in genetically clonal populations facilitates cellular adaptation to adverse environmental conditions while enabling a return to the basal physiological state. It also plays a crucial role in pathogenicity and the acquisition of drug resistance in unicellular organisms and cancer cells, yet the exact ...
Lukasz Kozubowski, Judith Berman, Kozubowski Lukasz   +2 more
exaly   +3 more sources

Fungal Drug Resistance: Azoles

2009
Azole antifungal agents are widely used in the clinical arena to treat a variety of fungal infections. The azoles inhibit fungal lanosterol demethylase, a key fungal enzyme in the ergosterol biosynthetic pathway, leading to an altered membrane physiology and, most frequently, a fungistatic effect.
Jose L. Lopez-Ribot, Thomas F. Patterson
openaire   +1 more source

Learning the ABC of oral fungal drug resistance

Molecular Oral Microbiology, 2015
SummaryATP‐binding cassette (ABC) proteins are ubiquitous in prokaryotes and eukaryotes. They are involved in energy‐dependent transport of molecules across membranes. ABC proteins are often promiscuous transporters that can translocate a variety of substrates.
R D, Cannon, A R, Holmes
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Fungal Biofilms: Agents of Disease and Drug Resistance

2014
Bacterial biofilms and their role in disease have been investigated in detail over 15 to 20 years, but research on fungal biofilms has traditionally lagged. Although other fungal species have been associated with biofilm formation, this chapter concentrates on Candida albicans since it is the fungal system that has received the most attention to date ...
Ramage, Gordon, Ghannoum, Mahmoud A., López-Ribot, José L.   +2 more
openaire   +1 more source

Fungal Drug Resistance Assays

2009
The increase in opportunistic mycosis as well as the emergence of antifungal resistance and the development of novel antifungal drugs necessitated the development of standard phenotypic drug resistance assays for fungi. Microdilution methods for testing yeasts (CLSI M27-A3 and EUCAST E.Def 7.2 assay) and filamentous fungi (CLSI M38-A2 and EUCAST E.Def ...
Sevtap Arikan, John H. Rex
openaire   +1 more source

Resistance of human fungal pathogens to antifungal drugs

Current Opinion in Microbiology, 2002
Resistance mechanisms can be engaged in clinically relevant fungal pathogens under different conditions when exposed to antifungal drugs. Over past years, active research was undertaken in the understanding of the molecular basis of antifungal drug resistance in these pathogens, and especially against the class of azole antifungals.
openaire   +3 more sources

INTRAVITREAL VORICONAZOLE FOR DRUG-RESISTANT FUNGAL ENDOPHTHALMITIS

Retina, 2006
To report the efficacy of intravitreal voriconazole.Retrospective analysis of an interventional case series of five cases of culture-proven fungal endophthalmitis treated with intravitreal voriconazole was done. Only cases found to be resistant to conventional antifungal agents were included in the study.
Parveen, Sen, Lingam, Gopal, Pratik Ranjan, Sen   +2 more
openaire   +2 more sources

Role of Mitochondria in Fungal Drug Resistance

2019
Incidences of opportunistic fungal infections and related mortality are growing threats to immunosuppressed patients. Limited arsenal in form of antifungals, along with emerging resistance, their toxicity and efficacy are the bottlenecks in successful treatment.
Ritu Pasrija, Deepika Kundu
openaire   +1 more source

Emerging Virulence, Drug Resistance and Future Anti-fungal Drugs for Candida Pathogens

Current Topics in Medicinal Chemistry, 2018
Increased incidences of Candida infection have augmented morbidity and mortality in human population, particularly among severely immunocompromised patients and those having a long stay in hospitals (nosocomial infections). Many virulence factors and fitness attributes are reported to be associated with the pathogenicity of Candida sp.
Vartika, Srivastava, Rajeev Kumar, Singla, Ashok Kumar, Dubey   +2 more
openaire   +2 more sources