Results 291 to 300 of about 543,044 (334)

Experimental evolution of drug resistance in human fungal pathogens

Current Opinion in Genetics & Development, 2022
Experimental evolution in vitro is a powerful tool to uncover the factors that contribute to resistance evolution and understand the genetic basis of adaptation. Here, we discuss recent experimental evolution studies from human fungal pathogens. We synthesize the results to highlight the common threads that influence resistance acquisition. The picture
Aleeza C, Gerstein, Parul, Sethi
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Fungal Biofilms: Agents of Disease and Drug Resistance

2014
Bacterial biofilms and their role in disease have been investigated in detail over 15 to 20 years, but research on fungal biofilms has traditionally lagged. Although other fungal species have been associated with biofilm formation, this chapter concentrates on Candida albicans since it is the fungal system that has received the most attention to date ...
Mahmoud A Ghannoum, Gordon Ramage, Jose L. Lopez-Ribot   +2 more
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Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance.

Current Topics in Medicinal Chemistry, 2021
No doubt antibiotics have saved billions of lives, but lack of novel antibiotics, development of resistance mechanisms in almost all clinical isolates of bacteria, and recurrent infections caused by persistent bacteria hamper the successful treatment of ...
H. Upadhyay
semanticscholar   +1 more source

Fungal Drug Resistance: Azoles

2009
Azole antifungal agents are widely used in the clinical arena to treat a variety of fungal infections. The azoles inhibit fungal lanosterol demethylase, a key fungal enzyme in the ergosterol biosynthetic pathway, leading to an altered membrane physiology and, most frequently, a fungistatic effect.
Jose L. Lopez-Ribot, Thomas F. Patterson
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Antifungal drug resistance in Candida: a special emphasis on amphotericin B

Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)
Invasive fungal infections in humans caused by several Candida species, increased considerably in immunocompromised or critically ill patients, resulting in substantial morbidity and mortality. Candida albicans is the most prevalent species, although the
Lailema Ahmady, Manisha Gothwal, Muhammed Mushthaque Mukkoli, V. K. Bari   +3 more
semanticscholar   +1 more source

Role of Mitochondria in Fungal Drug Resistance

2019
Incidences of opportunistic fungal infections and related mortality are growing threats to immunosuppressed patients. Limited arsenal in form of antifungals, along with emerging resistance, their toxicity and efficacy are the bottlenecks in successful treatment.
Deepika Kundu, Ritu Pasrija
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Pathogenesis of Fungal Infections and Drug-Resistance Phenomenon

2020
Fungi the primitive eukaryotes are emerging as life-threatening pathogens of public health. Over a decade and ago, the frequency of fungal infections has been enormous, with an increased range of mortality and morbidity in immunocompromised patients.
Pavani Sanapala, Sudhakar Pola, V. A. Iswarya Deepthi, Akella Vijayaramya   +3 more
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Resistance of human fungal pathogens to antifungal drugs

Current Opinion in Microbiology, 2002
Resistance mechanisms can be engaged in clinically relevant fungal pathogens under different conditions when exposed to antifungal drugs. Over past years, active research was undertaken in the understanding of the molecular basis of antifungal drug resistance in these pathogens, and especially against the class of azole antifungals.
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Short Guanidinium-Functionalized Poly(2-oxazoline)s Displaying Potent Therapeutic Efficacy on Drug-Resistant Fungal Infections.

Angewandte Chemie, 2022
New antifungals are urgently needed to combat invasive fungal infections, due to limited types of available antifungal drugs and frequently encountered side effects, as well as the quick emergence of drug-resistance. We previously developed amine-pendent
Weinan Jiang, Min Zhou, Zihao Cong, Jiayang Xie, Wenjing Zhang, Sheng Chen, Jingcheng Zou, Zhemin Ji, Ning Shao, Xin Chen, Maoquan Li, Runhui Liu   +11 more
semanticscholar   +1 more source

INTRAVITREAL VORICONAZOLE FOR DRUG-RESISTANT FUNGAL ENDOPHTHALMITIS

Retina, 2006
To report the efficacy of intravitreal voriconazole.Retrospective analysis of an interventional case series of five cases of culture-proven fungal endophthalmitis treated with intravitreal voriconazole was done. Only cases found to be resistant to conventional antifungal agents were included in the study.
Parveen Sen, Pratik Ranjan Sen, Lingam Gopal   +2 more
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