Results 291 to 300 of about 613,359 (339)

Experimental evolution of drug resistance in human fungal pathogens

Current Opinion in Genetics & Development, 2022
Experimental evolution in vitro is a powerful tool to uncover the factors that contribute to resistance evolution and understand the genetic basis of adaptation. Here, we discuss recent experimental evolution studies from human fungal pathogens. We synthesize the results to highlight the common threads that influence resistance acquisition. The picture
Aleeza C, Gerstein, Parul, Sethi
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INTRAVITREAL VORICONAZOLE FOR DRUG-RESISTANT FUNGAL ENDOPHTHALMITIS

Retina, 2006
To report the efficacy of intravitreal voriconazole.Retrospective analysis of an interventional case series of five cases of culture-proven fungal endophthalmitis treated with intravitreal voriconazole was done. Only cases found to be resistant to conventional antifungal agents were included in the study.
Parveen, Sen, Lingam, Gopal, Pratik Ranjan, Sen   +2 more
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Fungal Drug Resistance: Azoles

2009
Azole antifungal agents are widely used in the clinical arena to treat a variety of fungal infections. The azoles inhibit fungal lanosterol demethylase, a key fungal enzyme in the ergosterol biosynthetic pathway, leading to an altered membrane physiology and, most frequently, a fungistatic effect.
Jose L. Lopez-Ribot, Thomas F. Patterson
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Fungal Drug Resistance Assays

2009
The increase in opportunistic mycosis as well as the emergence of antifungal resistance and the development of novel antifungal drugs necessitated the development of standard phenotypic drug resistance assays for fungi. Microdilution methods for testing yeasts (CLSI M27-A3 and EUCAST E.Def 7.2 assay) and filamentous fungi (CLSI M38-A2 and EUCAST E.Def ...
Sevtap Arikan, John H. Rex
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Fungal Biofilms: Agents of Disease and Drug Resistance

2014
Bacterial biofilms and their role in disease have been investigated in detail over 15 to 20 years, but research on fungal biofilms has traditionally lagged. Although other fungal species have been associated with biofilm formation, this chapter concentrates on Candida albicans since it is the fungal system that has received the most attention to date ...
Ramage, Gordon, Ghannoum, Mahmoud A., López-Ribot, José L.   +2 more
openaire   +1 more source

Biomimetic Nanopillared Surfaces Inhibit Drug Resistant Filamentous Fungal Growth

ACS Applied Bio Materials, 2019
Filamentous fungi are invasive and multidrug resistant pathogens that commonly contaminate biomedical devices and implants. Once spherical fungal spores attach to a surface, they exhibit germ tube development, hyphal growth, and robust biofilm formation.
Rachel Rosenzweig, Michaela Marshall, Alex Parivar, Van K. Ly, Eric Pearlman, Albert F. Yee   +5 more
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Antifungal Drug Resistance of Dermatophytes Causing Superficial Fungal Infections

The Journal of Sylhet Women’s Medical College, 2022
Background: Superficial fungal infections (SFI) are common skin diseases that were largely simple to treat. However, due to increasing antimicrobial resistance (AMR) of dermatophytes to antifungal drugs, treatment of SFI has become difficult. This study aims to analyze the AMR of dermatophytes and to correlate with the clinical response of antifungal ...
null Chowdhury PA, null Azad AK, null Salam MU, null Ahmed MS, null Fatema K   +4 more
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Resistance of human fungal pathogens to antifungal drugs

Current Opinion in Microbiology, 2002
Resistance mechanisms can be engaged in clinically relevant fungal pathogens under different conditions when exposed to antifungal drugs. Over past years, active research was undertaken in the understanding of the molecular basis of antifungal drug resistance in these pathogens, and especially against the class of azole antifungals.
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Antifungal drug resistance in Candida: a special emphasis on amphotericin B

Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)
Invasive fungal infections in humans caused by several Candida species, increased considerably in immunocompromised or critically ill patients, resulting in substantial morbidity and mortality. Candida albicans is the most prevalent species, although the
Lailema Ahmady, Manisha Gothwal, Muhammed Mushthaque Mukkoli, V. K. Bari   +3 more
semanticscholar   +1 more source

Short Guanidinium-Functionalized Poly(2-oxazoline)s Displaying Potent Therapeutic Efficacy on Drug-Resistant Fungal Infections.

Angewandte Chemie, 2022
New antifungals are urgently needed to combat invasive fungal infections, due to limited types of available antifungal drugs and frequently encountered side effects, as well as the quick emergence of drug-resistance. We previously developed amine-pendent
Weinan Jiang, Min Zhou, Zihao Cong, Jiayang Xie, Wenjing Zhang, Sheng Chen, Jingcheng Zou, Zhemin Ji, Ning Shao, Xin Chen, Maoquan Li, Runhui Liu   +11 more
semanticscholar   +1 more source