Results 1 to 10 of about 736,835 (243)
Frontiers in Cellular and Infection Microbiology, 2023 Mastitis is one of the most prevalent diseases of dairy cows. Currently, mastitis treatment in dairy cows is mainly based on antibiotics. However, the use of antibiotics causes adverse effects, including drug resistance, drug residues, host-microbiome ...
Wei Guo +16 more
doaj +2 more sources
Exploring Drug Resistance: Microbial Profiles, Antibiotic Sensitivity, and Biofilm Development in Orthopedic Implant Infections. [PDF]
CureusBackground With the advent of and rise in antibiotic resistance globally, especially in postoperative patients, studying the antibiogram and associated factors is the need of the hour.
Sarkar K, Mullan S, Menon H.
europepmc +2 more sources
Steps to address anti-microbial drug resistance in today’s drug discovery [PDF]
Expert Opinion on Drug Discovery, 2018 There is no doubt that antimicrobial resistance (AMR) is one of the greatest health risks to emerge in the 21st century.
T. Parish
openaire +4 more sources
Microbial Persistence and the Road to Drug Resistance [PDF]
Cell Host & Microbe, 2013 Microbial drug persistence is a widespread phenomenon in which a subpopulation of microorganisms is able to survive antimicrobial treatment without acquiring resistance-conferring genetic changes. Microbial persisters can cause recurrent or intractable infections, and, like resistant mutants, they carry an increasing clinical burden.
Michael A. Lobritz +2 more
openaire +4 more sources
Chronic arsenic exposure and microbial drug resistance [PDF]
Proceedings of the National Academy of Sciences, 2013 Resistance to antimicrobial drugs represents one of the greatest threats to the control of infectious diseases and is a particular problem in treating diseases caused by parasitic protists. These pathogens are of enormous medical importance, causing diseases such as malaria, toxoplasmosis, trypanosomiasis, and leishmaniasis. In the absence of effective
Malcolm J. McConville, Stuart A. Ralph
openaire +4 more sources
Predicting allostery and microbial drug resistance with molecular simulations
Current Opinion in Structural Biology, 2018 Beta-lactamase enzymes mediate the most common forms of gram-negative antibiotic resistance affecting clinical treatment. They also constitute an excellent model system for the difficult problem of understanding how allosteric mutations can augment catalytic activity of already-competent enzymes.
Peter M. Kasson +2 more
openaire +5 more sources
Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens
Frontiers in Pharmacology, 2021 Antibiotic resistance or microbial drug resistance is emerging as a serious threat to human healthcare globally, and the multidrug-resistant (MDR) strains are imposing major hurdles to the progression of drug discovery programs.
Tushar Khare +8 more
doaj +2 more sources
Infection and Drug Resistance, 2018 Balew Arega,1,2 Yimtubezinash Woldeamanuel,2 Kelemework Adane,3 Abdulaziz A Sherif,4 Daniel Asrat2 1College of Health Sciences, Debre Markos University, Debre Markos, 2Department of Microbiology, Immunology, and Parasitology, School of Medicine, College ...
Arega B +4 more
doaj +2 more sources
Microbial extracellular vesicles contribute to antimicrobial resistance.
PLoS PathogensWith the escalating global antimicrobial resistance crisis, there is an urgent need for innovative strategies against drug-resistant microbes. Accumulating evidence indicates microbial extracellular vesicles (EVs) contribute to antimicrobial resistance ...
Bowei Jiang +6 more
doaj +2 more sources
Modeling microbial drug-resistance: from mathematics to pharmacoeconomics
Фармакоэкономика, 2018 Complicated intra-abdominal infection (IAI) requires increased health care expenditures and additional resources to compensate for an ineffective starting therapy.Aim. To select the economically optimal algorithm for using antimicrobial agents (AMA) that
Yu. M. Gomon +6 more
doaj +4 more sources