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Exploring Drug Resistance: Microbial Profiles, Antibiotic Sensitivity, and Biofilm Development in Orthopedic Implant Infections. [PDF]
CureusBackground With the advent of and rise in antibiotic resistance globally, especially in postoperative patients, studying the antibiogram and associated factors is the need of the hour.
Sarkar K, Mullan S, Menon H.
europepmc +2 more sources
Advancing Antimicrobial Resistance Research Through Quantitative Modeling and Synthetic Biology [PDF]
Frontiers in Bioengineering and Biotechnology, 2020 Antimicrobial resistance (AMR) is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050.
Kevin S. Farquhar +2 more
doaj +2 more sources
Microbial Persistence and the Road to Drug Resistance [PDF]
Cell Host & Microbe, 2013 Microbial drug persistence is a widespread phenomenon in which a subpopulation of microorganisms is able to survive antimicrobial treatment without acquiring resistance-conferring genetic changes. Microbial persisters can cause recurrent or intractable infections, and, like resistant mutants, they carry an increasing clinical burden.
Michael A. Lobritz +2 more
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Approaches for Mitigating Microbial Biofilm-Related Drug Resistance: A Focus on Micro- and Nanotechnologies [PDF]
Molecules, 2021 Biofilms play an essential role in chronic and healthcare-associated infections and are more resistant to antimicrobials compared to their planktonic counterparts due to their (1) physiological state, (2) cell density, (3) quorum sensing abilities, (4) presence of extracellular matrix, (5) upregulation of drug efflux pumps, (6) point mutation and ...
Harinash Rao +6 more
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Steps to address anti-microbial drug resistance in today’s drug discovery [PDF]
Expert Opinion on Drug Discovery, 2018 There is no doubt that antimicrobial resistance (AMR) is one of the greatest health risks to emerge in the 21st century.
T. Parish
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Chronic arsenic exposure and microbial drug resistance [PDF]
Proceedings of the National Academy of Sciences, 2013 Resistance to antimicrobial drugs represents one of the greatest threats to the control of infectious diseases and is a particular problem in treating diseases caused by parasitic protists. These pathogens are of enormous medical importance, causing diseases such as malaria, toxoplasmosis, trypanosomiasis, and leishmaniasis. In the absence of effective
Malcolm J. McConville, Stuart A. Ralph
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Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens
Frontiers in Pharmacology, 2021 Antibiotic resistance or microbial drug resistance is emerging as a serious threat to human healthcare globally, and the multidrug-resistant (MDR) strains are imposing major hurdles to the progression of drug discovery programs.
Tushar Khare +8 more
doaj +2 more sources
Predicting allostery and microbial drug resistance with molecular simulations
Current Opinion in Structural Biology, 2018 Beta-lactamase enzymes mediate the most common forms of gram-negative antibiotic resistance affecting clinical treatment. They also constitute an excellent model system for the difficult problem of understanding how allosteric mutations can augment catalytic activity of already-competent enzymes.
Peter M. Kasson +2 more
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Infection and Drug Resistance, 2018 Balew Arega,1,2 Yimtubezinash Woldeamanuel,2 Kelemework Adane,3 Abdulaziz A Sherif,4 Daniel Asrat2 1College of Health Sciences, Debre Markos University, Debre Markos, 2Department of Microbiology, Immunology, and Parasitology, School of Medicine, College ...
Arega B +4 more
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Hygiene: microbial strategies to reduce pathogens and drug resistance in clinical settings
Microbial Biotechnology, 2017 SummaryHealthcare‐associated infections (HAIs) are a global concern, affecting all western hospitals, and profoundly impairing the clinical outcome of up to 15% of all hospitalized patients. Persistent microbial contamination of hospital surfaces has been suggested to contribute to HAIs onset, representing a reservoir for hospital pathogens.
E. Caselli
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