Results 191 to 200 of about 9,006,960 (303)

Mechanism-Base Pharmacokinetic-Pharmacodynamic Modeling of Cefquinome Against <i>Streptococcus suis</i> Serotype 2 Under Different Inoculum and Susceptibility Conditions. [PDF]

Med Sci (Basel)
Mestareehi AH.
europepmc   +1 more source

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

Advanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu, Jingyu Yu, Suhui Wang, Xinghong Hu, Lele Jin, Nan Wu, Yuhan Ni, Xueying Zhang, Chengling Zhao, Jihong Zhou, Yong Zhang, Baofa Sun, Hongxing Zhang, Chunfu Zheng, Song Guo Zheng, Wei Li, Xinxing Zhu   +16 more
wiley   +1 more source

Comparative and Subtractive Genomics Analysis of Multidrug-Resistant <i>Klebsiella pneumoniae</i> Strains for Novel Target Identification and Drug Repurposing Strategies. [PDF]

Int J Microbiol
Bora M, Paul P, Rajkhowa S, Sonar H, Gohain BB, Zaki MEA, Prabhu D.   +6 more
europepmc   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Phage Therapy Enhanced by Using Engineered Bacteriophages: A Powerful Antibacterial Tool to Address the Dilemma Posed by Multidrug-Resistant Bacterial Infections. [PDF]

Int J Mol Sci
Wang X, Zhou H, Lim TS, Węgrzyn G.
europepmc   +1 more source

Enhanced Antibacterial Properties of Lyotropic Liquid Crystalline Nanoparticles via Curvature Modulation

Advanced Science, EarlyView.
Lipid nanostructured particles with increasing negative Gaussian curvature progress from vesicles to P‐cubosomes and D‐cubosomes. This curvature hierarchy enhances interaction with bacterial membranes, promotes membrane remodeling and leakage, and potentiates daptomycin activity against MRSA.
Xiangfeng Lai, Shuhong Wang, Chenguang Ding, Xenia Kostoulias, Anton P. Le Brun, Hsien‐Yi Hsu, Jhih‐Hang Jiang, Yajun Wang, Richard A. Strugnell, Anton Y. Peleg, Hsin‐Hui Shen   +10 more
wiley   +1 more source

Research Status and Prospects of <i>Helicobacter pylori</i>-associated gastritis: From Mechanisms to Traditional Chinese Medicine Treatment. [PDF]

Gastroenterol Res Pract
Fan Z, Jin Z, Liu C, Hu R, Li W.
europepmc   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

Heteroresistance in <i>Mycobacterium tuberculosis</i>: from molecular mechanisms and advanced detection to clinical implications. [PDF]

Front Cell Infect Microbiol
Liu S, Chen D, Zhang J, Zhu M.
europepmc   +1 more source

[Positioning of various anti-bacterial agents and their appropriate use in the era of multiple bacterial drug resistance. 6. Aminoglycosides].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2004
Mitsuo, Sakamoto, Fumiya, Sato, Koya, Shiba   +2 more
openaire   +1 more source