Results 211 to 220 of about 9,006,960 (303)

Molecular mechanisms of antibiotic resistance in Gram-positive and Gram-negative bacteria - a narrative review. [PDF]

Front Cell Infect Microbiol
Tonco DC, Gavrilovici C, Lupu A, Pertea LI, Ioniuc I, Grudnicki A, Anton SC, Nedelcu AH, Rusu T, Mitrofan C, Rosu MF, Morariu ID, Anton E, Mitrofan EC, Lupu VV.   +14 more
europepmc   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Detection of carbapenem resistance mechanisms in difficult-to-treat Pseudomonas aeruginosa clinical isolates from a tertiary care hospital in Egypt. [PDF]

BMC Microbiol
Salem D, Zaiton M, El-Shenawy A, Dahroug H, El-Dein S, Gamal D, Althoqapy AA, Mohamed AA, Shemis MA, Diab M, Maklad SS.   +10 more
europepmc   +1 more source

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, EarlyView.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

Innovative approaches to therapeutic target discovery amid the global challenge of antimicrobial resistance. [PDF]

J Comput Aided Mol Des
de Oliveira Teixeira T, da Silva RCC, Alves MCS, de Araujo Silva R, Echeverria JES, Simionatto S.   +5 more
europepmc   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

Fatty Acid Biosynthesis Inhibitors─Fabimycin and Triclosan─Trigger Distinct Resistance Mutations in FabI and Potently Kill Gram-Negative Pathogens. [PDF]

ACS Infect Dis
Cain BN, Kent JE, Elane M, Williams JD, Lee MR, Lau GW, Hergenrother PJ, Osterman AL.   +7 more
europepmc   +1 more source

Two‐Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment

Advanced Science, EarlyView.
A new class of Cu, Ni bimetallic 2D cMOF (CuNi‐HHTP 2D cMOF) featuring dual catalytic sites and high delocalized electronic structure for boosting POD performance. The CuNi‐HHTP 2D‐cMOF enhances the conversion kinetics of H2O2 to ROS, which subsequently enhances antibacterial activity and accelerates the healing of oral ulcers, with macroscopic wound ...
Yixuan Lu, Qinqin Li, Yumin Chen, Shihan Zhang, Shuai Ding, Yanpei Wang, Youxing Liu, Yaru Guo, Xuliang Deng, Shaojun Guo   +9 more
wiley   +1 more source

Clinical Impact of Multidrug-Resistant Bacterial Infections in Critically Ill Patients: A Retrospective Cohort Study. [PDF]

J Clin Med
Bartoszewicz M, Płonowska E, Krysik M, Ładny JR, Czaban SL.   +4 more
europepmc   +1 more source