Results 251 to 260 of about 1,436,718 (300)

Multiple drug resistance, antimutagenesis and anticarcinogenesis

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
Many cells are protected from excess levels of exogenous chemicals, including mutagens and carcinogens as well as pharmaceutical agents, by being actively extruded through the action of one or more of a series of ATP-binding cassette drug transporter proteins. Those known to be important in humans are the multidrug resistance proteins (P-glycoproteins,
L. R. FERGUSON, DE FLORA, SILVIO
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Topoisomerase II in multiple drug resistance

Cytotechnology, 1993
Topoisomerase II is a target of alkaloid, anthracycline and related antitumor agents. Two types of multiple drug resistance are associated with these enzymes. In classical (typical) multidrug resistance, inhibitors are actively effluxed from cells by P-glycoprotein.
G A, Hofmann, M R, Mattern
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Drug resistance in multiple myeloma.

Seminars in hematology, 1997
The development of multidrug resistance (MDR) is a major obstacle to improving treatment outcomes in multiple myeloma. Recent studies have indicated that several specific mechanisms of MDR may be involved in clinically refractory multiple myeloma patients, such as expression of P-glycoprotein (P-gp), expression of the lung-resistance protein (LRP) and ...
Sonneveld, Pieter, Lokhorst, HM, Vossebelt, PJM   +2 more
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ChemInform Abstract: Multiple Drug Resistance

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lester A. Mitscher, Segaran P. Pillai, Elmer J. Gentry, Delbert M. Shankel   +3 more
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Topoisomerase I in multiple drug resistance

Cytotechnology, 1993
Topoisomerase I is a nuclear enzyme able to catalyse the relaxation of supercoiled DNA by introducing single-stranded breaks in DNA molecule. Its function seems important to prepare DNA for many processes such as recombination, DNA repair and RNA transcription.
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Multiple Drug Resistance Mechanisms in Cancer

Molecular Biotechnology, 2010
Multiple drug resistance (multidrug resistance; MDR), a phenomenon whereby human tumours that acquire resistance to one type of therapy are found to be resistant to several other drugs that are often quite different in both structure and mode of action, has been recognised clinically for several decades. An important advance in our understanding of MDR
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Molecular cytogenetics of multiple drug resistance

Cytotechnology, 1993
The refractory nature of many human cancers to multi-agent chemotherapy is termed multidrug resistance (MDR). In the past several decades, a major focus of clinical and basic research has been to characterize the genetic and biochemical mechanisms mediating this phenomenon.
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Drug resistance and drug development in multiple myeloma

Seminars in Oncology, 2002
Circumvention of drug resistance in multiple myeloma is a major obstacle to improving clinical outcomes for myeloma patients. Identification of several mechanisms of acquired drug resistance has led to the development of chemosensitizing agents that counter specific drug resistance mechanisms.
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Transmissible Drug-resistance Factors and Formation of Multiple Resistance

Nature, 1962
IN earlier reports several types of drug (chloramphenicol, Cm; tetracycline, Tc; streptomycin, Sm; sulphanilamide, Da) resistant Escherichia coli and Shigella were described1–3. It was also found that seven types of drug resistance are transmitted by cell-to-cell contact4.
S, MITSUHASHI, K, HARADA
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Drug resistance in multiple myeloma.

Pathologie-biologie, 1999
Multidrug resistance (MDR) is a pleiotropic resistance against several unrelated drugs. It may be induced by prolonged exposure of cells to drugs such as doxorubicin, etoposide and vinca alkaloids. Once MDR develops in clinical tumors, it is a major obstacle for the improvement of treatment of multiple myeloma (MM).
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