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ncRNAs associated with drug resistance and the therapy of digestive system neoplasms
Journal of Cellular Physiology, 2019AbstractDigestive system cancer remains a common cancer and the main cause of cancer‐related death worldwide. Drug resistance is a major challenge in the therapy of digestive system cancer, and represents a primary obstacle in the treatment of cancer by restricting the efficiency of both traditional chemotherapy and biological therapies.
Wei Feng +5 more
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[Correlation between C219 and drug resistance in lung neoplasms].
Minerva medica, 1993The authors take into consideration 19 cases of lung neoplasm to see the relationship of clinical behaviour and C219. They found a cutoff (25%) to separate drug resistant by drug sensibility. Marker sensitivity was 84.2% and relation with PCNA was negative (-0.384).
G, Oddi +4 more
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The genetic origin of drug resistance in neoplasms: implications for systemic therapy.
Cancer research, 1984Drug resistance continues to be a major factor in limiting the effectiveness of cancer chemotherapy. Evidence from a variety of sources implicates a genetic basis for most drug-resistant phenotypes. Assuming a random spontaneous origin for these resistant cells, it is possible to develop mathematical and computer-based models of the drug treatment of ...
J H, Goldie, A J, Coldman
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Laboratory detection of primary and acquired drug resistance in human lymphatic neoplasms.
Cancer treatment reports, 1986We tested the ability of the differential staining cytotoxicity (DiSC) assay to discriminate between sensitive and resistant cell populations in human lymphatic neoplasms. First, the in vitro activity spectra of the most important drugs paralleled the known clinical activity spectra of the same agents. Second, there were highly significant correlations
L M, Weisenthal +5 more
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Zhonghua fu chan ke za zhi, 2011
To evaluate the efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm (GTN) patients, and investigate factors influencing the outcome of the surgery combined with chemotherapy.Medical records of 42 patents with drug-resistant GTN who were treated by chemotherapy combined with ...
Feng-Zhi, Feng +5 more
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To evaluate the efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm (GTN) patients, and investigate factors influencing the outcome of the surgery combined with chemotherapy.Medical records of 42 patents with drug-resistant GTN who were treated by chemotherapy combined with ...
Feng-Zhi, Feng +5 more
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Cancer treatment reports, 1988
Fresh specimens of human lymphatic neoplasms were tested with the differential staining cytotoxicity assay. Cells from relapsed patients with acute lymphoblastic leukemia (ALL) were significantly more resistant to vincristine, dexamethasone, and doxorubicin in the assay than were cells from previously untreated patients.
L M, Weisenthal +4 more
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Fresh specimens of human lymphatic neoplasms were tested with the differential staining cytotoxicity assay. Cells from relapsed patients with acute lymphoblastic leukemia (ALL) were significantly more resistant to vincristine, dexamethasone, and doxorubicin in the assay than were cells from previously untreated patients.
L M, Weisenthal +4 more
openaire +1 more source
Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
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