Results 31 to 40 of about 464,133 (328)
Cervical cancer heterogeneity: a constant battle against viruses and drugs
Biomarker Research, 2022 Cervical cancer is the first identified human papillomavirus (HPV) associated cancer and the most promising malignancy to be eliminated. However, the ever-changing virus subtypes and acquired multiple drug resistance continue to induce failure of tumor ...
Qian Sun +4 more
doaj +1 more source
Synthesis and Antitumor Activity of a GSH Inert Bisphosphonate Platinum (II) Complex
Journal of Chemistry, 2022 Osteosarcoma is a highly aggressive neoplasm. Traditional platinum chemotherapeutic agents for osteosarcoma inevitably have acquired drug resistance and serious side effects, which have limited their utility.
Lu Ma +7 more
doaj +1 more source
Advancing Drug Resistance Research Through Quantitative Modeling and Synthetic Biology [PDF]
Frontiers in Bioengineering and Biotechnology, 8: 583415 (2020), 2020 Antimicrobial resistance is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050. Research over the last decade has demonstrated that the differences between genetically identical cells in the same environment can lead to drug resistance ...
arxiv +1 more source
Does Non-Genetic Heterogeneity Facilitate the Development of Genetic Drug Resistance? [PDF]
BioEssays, 43: e2100043 (2021), 2021 Non-genetic forms of antimicrobial drug resistance can result from cell-to-cell variability that is not encoded in the genetic material. Data from recent studies also suggest that non-genetic mechanisms can facilitate the development of genetic drug resistance.
arxiv +1 more source
Metabolic Reprogramming in Thyroid Cancer [PDF]
Endocrinology and MetabolismThyroid cancer is a common endocrine malignancy with increasing incidence globally. Although most cases can be treated effectively, some cases are more aggressive and have a higher risk of mortality.
Sang-Hyeon Ju +5 more
doaj +1 more source
Protein-Functionalized Microgel for Multiple Myeloma Cells’ 3D Culture
Biomedicines, 2022 Multiple myeloma is a hematologic neoplasm caused by an uncontrolled clonal proliferation of neoplastic plasma cells (nPCs) in the bone marrow. The development and survival of this disease is tightly related to the bone marrow environment.
Juan Carlos Marín-Payá +5 more
doaj +1 more source
Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma
Frontiers in Pharmacology, 2021 Multiple myeloma (MM) is a plasma cells neoplasm. The overexpression of Bcl-2 family proteins, particularly myeloid cell leukemia 1 (Mcl-1), plays a critical role in the pathogenesis of MM.
Omar S. Al-Odat +12 more
doaj +1 more source
Pharmaceutics, 2023 Primary malignant brain tumors are the most common solid neoplasm in childhood. Despite recent advances, many children affected by aggressive or metastatic brain tumors still present poor prognosis, therefore the development of more effective therapies ...
L. Abballe +6 more
semanticscholar +1 more source
Essential procedures of single-cell RNA sequencing in multiple myeloma and its translational value
Blood Science, 2023 Multiple myeloma (MM) is a malignant neoplasm characterized by clonal proliferation of abnormal plasma cells. In many countries, it ranks as the second most prevalent malignant neoplasm of the hematopoietic system.
Jun Du +4 more
doaj +1 more source
Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death. [PDF]
PLoS ONE, 2012 Multiple Myeloma (MM) is a lymphatic neoplasm characterized by clonal proliferation of malignant plasma cell that eventually develops resistance to chemotherapy.
Liat Josefsberg Ben-Yehoshua +6 more
doaj +1 more source