Results 121 to 130 of about 334,676 (308)

Hydrogel Microtube Drug Carrier for Catheter‐Based Intravascular Therapy

Advanced Healthcare Materials, EarlyView.
This paper proposes hydrogel microtube carriers composed of barium alginate gel, enabling long‐term vascular retention without interrupting blood flow. Intravascular treatments have long been attracting attention for therapeutic efficacy, yet practical delivery methods remained unestablished.
Shota Sato, Hiroki Ohta, Naoki Takakura, Kentaro Kasa, Teppei Komatsu, Dai Kejia, Misato Yoshioka, Hirotaka James Okano, Hiroaki Onoe   +8 more
wiley   +1 more source

Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat [PDF]

, 2010
Background: The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-
Sakalian Michael, Karl Salzwedel, Salzwedel Karl, Catherine S. Adamson, Eric O. Freed, Sakalian, M, Michael Sakalian, Adamson, Catherine S, Salzwedel, K, Freed Eric O, Freed, E.O., Adamson Catherine S   +11 more
core   +1 more source

SARS-CoV-2 drug resistance and therapeutic approaches

Heliyon
In light of the transition of COVID-19 from a pandemic to an endemic phase, there is still a dire need to address challenges associated with drug resistance, particularly among immunocompromised and high-risk populations. This review explores the current
Sania Batool, Santosh Chokkakula, Ju Hwan Jeong, Yun Hee Baek, Min-Suk Song   +4 more
doaj   +1 more source

Prevention of viral drug resistance by novel combination therapy.

Current opinion in investigational drugs (London, England : 2000), 2001
A new form of antiviral clinical therapy is proposed in which three different drugs are administered against three different targets on the same virus-coded protein. If the physiological functions of the three different target sites are not independent of each other, then a mutation conferring drug resistance at one site may alter the physiological ...
Mangel, W. F., Brown, M. T., Baniecki, M. L., Barnard, Dale L., McGrath, W. J.   +4 more
openaire   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Drug resistance [PDF]

Part of series 1 of the CDC Museum set of Infectious disease trading cards, featuring photos and information about some of the infectious diseases that CDC studies.Drug resistance happens when antimicrobial drugs\u2013some of which are called antibiotics\

core  

The emergence of YMDD mutants precedes biochemical flare by 19 weeks in lamivudine-treated chronic hepatitis B patients: an opportunity for therapy reevaluation

Brazilian Journal of Medical and Biological Research, 2007
Given the loss of therapeutic efficacy associated with the development of resistance to lamivudine (LMV) and the availability of new alternative treatments for chronic hepatitis B patients, early detection of viral genotypic resistance could allow the ...
P.H.C. França, H.S.M. Coelho, C.E. Brandão, J.A. Segadas, R.F. Quintaes, F.J. Carrilho, S. Ono-Nita, A.A. Mattos, C. Tovo, V.S. Gouvea, E. Sablon, B.O.M. Vanderborght   +11 more
doaj  

Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance

Cell
DNA polymerases are important drug targets, and many structural studies have captured them in distinct conformations. However, a detailed understanding of the impact of polymerase conformational dynamics on drug resistance is lacking. We determined cryoelectron microscopy (cryo-EM) structures of DNA-bound herpes simplex virus polymerase holoenzyme in ...
Shankar, Sundaresh, Pan, Junhua, Yang, Pan, Bian, Yuemin, Oroszlán, Gábor, Yu, Zishuo, Mukherjee, Purba, Filman, David J, Hogle, James M, Shekhar, Mrinal, Coen, Donald M, Abraham, Jonathan   +11 more
openaire   +3 more sources

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

Resistance to protease inhibitors among persons living with HIV in Ghana: a case for viral load and drug resistance monitoring

Virology Journal
Objective Routine viral load and drug resistance testing are well supported in most resource-rich settings and provide valuable benefits in the clinical care of PLWH in these communities.
Makafui Seshie, Billal Musah Obeng, Vivian Etsiapa Boamah, Marcel Bayor, Evelyn Yayra Bonney, Stephen Yao Gbedema, Kwamena William Coleman Sagoe   +6 more
doaj   +1 more source