Results 271 to 280 of about 505,639 (311)

Genotypic antiretroviral drug resistance testing at low viral loads in the UK

HIV Medicine, 2008
BackgroundAntiretroviral drug resistance testing is recommended in HIV‐1 infected patients failing therapy in order to inform treatment selection. Although guidelines and test manufacturers recommend a viral load of at least 500–1000 HIV‐1 RNA copies/mL for genotypic resistance testing to be performed, prompt management of virological failure could ...
Cane, P. A., Kaye, S., Smit, E., Tilston, P., Kirk, S., Shepherd, J., Hopkins, M., Zhang, H., Geretti, A. M.   +8 more
openaire   +4 more sources

Effects of drug resistance on viral load in patients failing antiretroviral therapy

Journal of Medical Virology, 2006
Previous studies on patients who develop drug resistant HIV-1 variants have shown that continued use of failing regimens might provide clinical benefit. However, the effect of long-term exposure to drug resistant variants may lead to emergence of compensatory mutations that may jeopardize this effect.
Machouf, N., Thomas, R., Nguyen, V., Trottier, B., Boulassel, M., Wainberg, M., Routy, J.   +6 more
openaire   +3 more sources

Models of Viral Kinetics and Drug Resistance in HIV-1 Infection

AIDS Patient Care and STDs, 1998
Mathematical models have become an increasingly valuable tool in HIV research. In particular, the mathematical analysis of drug-induced perturbations of the steady-state viral load in chronically infected patients has led to fundamental new insights into HIV dynamics in vivo and demonstrated that there is highly active viral replication throughout the ...
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Viral quasispecies and the problem of vaccine-escape and drug-resistant mutants

1997
Since a first version of this article on the relevance of quasispecies to viral disease control was published by one of us [1], an explosion of information on viral quasispecies has been gathered by several groups. For many viruses, extreme complexity at the population level has been documented by direct copying into cDNA of viral RNA extracted from ...
E, Domingo, L, Menéndez-Arias, M E, Quiñones-Mateu, A, Holguín, M, Gutiérrez-Rivas, M A, Martínez, J, Quer, I S, Novella, J J, Holland   +8 more
openaire   +2 more sources

The effect of transmitted HIV-1 drug resistance on pre-therapy viral load

AIDS, 2010
Reduced replication capacity of viruses expressing drug resistant mutations implies that patients with transmitted drug resistance (TDR) could have lower HIV RNA viral load than those infected with wild-type virus.We performed analysis using data from the UK HIV Drug Resistance Database and the UK CHIC study.
Harrison, Linda, Castro, Hannah, Cane, Patricia, Pillay, Deenan, Booth, Clare, Phillips, Andrew, Geretti, Anna Maria, Dunn, David, Post, Frank   +8 more
openaire   +3 more sources

The impact of the M184V substitution on drug resistance and viral fitness

Expert Review of Anti-infective Therapy, 2004
Treatment of HIV/AIDS with antiretroviral therapy can result in HIV-1 drug resistance, limiting its use. Resistance mutations arise prior to therapy due to errors in HIV-1 replication, and are also spread by sexual and other modes of transmission. However, it is also generally believed that resistance is due to multiple drug mutations to any single or ...
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Efficiency of Drug Resistance Genotypic Tests in Specimens with Low HIV Viral Load

Antiviral Therapy, 1999
The early recognition of resistance to antiretroviral agents could allow a rapid switch in therapy and therefore avoid the accumulation of mutations and reduce the risk of cross-resistance. However, the efficiency of genotypic tests in specimens with low viral load (VL) is severely compromised since human immunodeficiency virus (HIV) RNA in these ...
M, Gómez-Cano, A, Rubio, L, Ruiz, M, Pérez-Olmeda, M, Leal, B, Clotet, V, Soriano   +6 more
openaire   +2 more sources

Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections

The Lancet Infectious Diseases, 2017
Antibiotics have revolutionised medicine in many aspects, and their discovery is considered a turning point in human history. However, the most serious consequence of the use of antibiotics is the concomitant development of resistance against them. The marine environment has proven to be a very rich source of diverse natural products with significant ...
Abdelmohsen, Usama Ramadan, Balasubramanian, Srikkanth, Oelschlaeger, Tobias A, Grkovic, Tanja, Ngoc, B Pham, Quinn, Ronald J, Hentschel, Ute   +6 more
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Use of Viral Resistance Patterns to Antiretroviral Drugs in Optimising Selection of Drug Combinations and Sequences

Drugs, 1996
High rates of viral replication throughout HIV infection, and the frequency of mutation occurring during each replication cycle due to the inaccuracy of reverse transcriptase, drive the potential for drug-resistant viral variants to appear under the selective pressure of antiretroviral therapy.
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Viral Proteases as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation

2016
Viral proteases have been shown to be effective targets of anti-viral therapies for human immunodeficiency virus (HIV) and hepatitis C virus (HCV). However, under the pressure of therapy including protease inhibitors, the virus evolves to select drug resistance mutations both in the protease and substrates. In my thesis study, I aimed to understand the
openaire   +2 more sources