Results 261 to 270 of about 2,302,594 (308)
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Drug Discovery Today: Technologies, 2014
Drug resistance is a fundamental problem in the treatment of cancer since cancer that becomes resistant to the available drugs may leave the patient with no therapeutic alternatives. In this chapter, we consider the dynamics of drug resistance in blood cancer and the related issue of the dynamics of cancer stem cells. After describing the main types of
Gemma, Texidó, Jürgen, Moll
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Drug resistance is a fundamental problem in the treatment of cancer since cancer that becomes resistant to the available drugs may leave the patient with no therapeutic alternatives. In this chapter, we consider the dynamics of drug resistance in blood cancer and the related issue of the dynamics of cancer stem cells. After describing the main types of
Gemma, Texidó, Jürgen, Moll
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British Medical Bulletin, 1991
Chemotherapy cures a minority of adult tumours (e.g. Hodgkin's and non-Hodgkin's lymphoma, acute leukaemia, teratoma) and the majority of childhood tumours. Prolongation of survival by chemotherapy has been shown for small cell lung cancer, ovarian cancer and breast carcinoma (when used as an adjuvant).
D, Hochhauser, A L, Harris
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Chemotherapy cures a minority of adult tumours (e.g. Hodgkin's and non-Hodgkin's lymphoma, acute leukaemia, teratoma) and the majority of childhood tumours. Prolongation of survival by chemotherapy has been shown for small cell lung cancer, ovarian cancer and breast carcinoma (when used as an adjuvant).
D, Hochhauser, A L, Harris
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Multi-Drug Resistant and Extensively-Drug Resistant Tuberculosis
The Indian Journal of Pediatrics, 2020India is one of the high burden countries for tuberculosis (TB) including multi-drug resistant TB (MDR-TB) and extensively-drug resistant (XDR) TB. Drug-resistant (DR) TB has threatened the TB care and is a major health problem in many countries; treatment of DR TB has been difficult requiring use of reserve or second-line drugs, cost factors, has ...
Ira, Shah +2 more
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Drug resistance in schistosomes
Parasitology Today, 1993Drug resistance in schistosomes is confined essentially to compounds of the hyconthone/oxamniquine family, since no documented case of resistance has so far been reported for the widely used drug praziquantel. The availability of strains of Schistosoma mansoni that are resistant to hyconthone and oxomniquine has permitted a detailed genetic and ...
Cioli D, PicaMattoccia L, Valle C
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The Lancet Neurology, 2023
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other factors such as age of seizure onset and presence of associated neurological deficits.
Emilio Perucca +3 more
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Drug resistance is estimated to affect about a third of individuals with epilepsy, but its prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other factors such as age of seizure onset and presence of associated neurological deficits.
Emilio Perucca +3 more
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2012
Abstract Despite the ongoing development of novel AEDs, drug resistance remains a major problem in the clinical management of epilepsy patients. Thus, strategies to break new grounds in the development of novel AEDs or alternative therapeutic approaches are urgently needed.
Gorter, J.A., Potschka, H.
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Abstract Despite the ongoing development of novel AEDs, drug resistance remains a major problem in the clinical management of epilepsy patients. Thus, strategies to break new grounds in the development of novel AEDs or alternative therapeutic approaches are urgently needed.
Gorter, J.A., Potschka, H.
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Resistance to the nitroheterocyclic drugs
Acta Tropica, 1994The nitroheterocyclic drugs have been available since the early 1960's for the treatment of anaerobic protozoa. The application of these drugs has widened since then and they are presently used to treat anaerobic pathogenic bacteria and protozoa. The activity of the nitroheterocyclic drugs depends on the all-important nitro group attached to the ...
S M, Townson +3 more
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New England Journal of Medicine, 1996
Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections. However, it was soon evident that bacterial pathogens were unlikely to surrender unconditionally, because some pathogens rapidly became resistant to many of the first effective drugs.
H S, Gold, R C, Moellering
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Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections. However, it was soon evident that bacterial pathogens were unlikely to surrender unconditionally, because some pathogens rapidly became resistant to many of the first effective drugs.
H S, Gold, R C, Moellering
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New England Journal of Medicine, 2011
Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
Patrick, Kwan +2 more
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Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
Patrick, Kwan +2 more
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Annual Review of Pharmacology and Toxicology, 1992
Infection with human immunodeficiency virus (HIV) is a chronic process with persistent, high rates of replication. The virus exhibits high rates of mutation over time within the same individual. It is thus not surprising that drug-resis tant mutants of HIV emerge under the selective pressure of prolonged chemotherapy, especially with the knowledge of ...
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Infection with human immunodeficiency virus (HIV) is a chronic process with persistent, high rates of replication. The virus exhibits high rates of mutation over time within the same individual. It is thus not surprising that drug-resis tant mutants of HIV emerge under the selective pressure of prolonged chemotherapy, especially with the knowledge of ...
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